Cancer Cell
Research 
Cancercellresearch 2023, 9(36), 897-902;
- 25 Mar. 2023
Abstract
: Glioma is the most common primary tumor of the central nervous
system and the tumor genetics of glioma has been a hot topic. In
recent years, the role of ecDNA in tumors, especially glioma, has
been gradually recognized.
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: Glioma is the most common primary tumor of the central nervous
system and the tumor genetics of glioma has been a hot topic. In
recent years, the role of ecDNA in tumors, especially glioma, has
been gradually recognized. ecDNA can accelerate tumor evolution and
mediate glioma drug resistance activity by randomly distributing in
the interphase due to the lack of mitotic structure. The circle
structure of ecDNA also has the characteristics of high openness,
strong transcriptional activity and diverse regulatory modes. The
study of glioma ecDNA has gone through three stages: classical
karyotype analysis, basic function study and regulatory molecular
mechanism study. In the era of karyotype analysis, early studies
focused mostly on the description of cell karyotypes, but later
merged with research on oncogenes. In the era of functional study of
ecDNA, not only have many oncogenes located on ecDNA had been
discovered, but also the mechanism of ecDNA involvement in glioma
drug resistance had been revealed. In the past five years, the finer
molecular regulatory mechanisms have become essential in further
revealing the unique functions of ecDNA, mainly due to the
advancement of biology experiments research tools and bioinformatics
technologies.
Full article
(This article belongs to the Section Cancer cell Research)