Monday, 9.03.2015  

  

Cancer Cell Research (Online ISSN: 2161-2609)


Current Issue

No.1 Vol.7


Article: To evaluate if the prognosis of curative resection in HCC patients is affected by alcholism
by Tao Liu, Liqun Wu
Cancer Cell Research 2015 1(7) 
						144-151; published online 9 March 2015
Abstract: To investigate the relationship of alcoholism history and prognosis of the patients with primary hepatocellular carcinoma (HCC) after curative resection. The clinical data of 606 cases of primary HCC underwent curative resection from January 2001 to December 2011 in Affiliated Hospital of Medical College Qingdao University were analyzed retrospectively. By Kaplan-Meier method, median overall survival (OS) in alcoholism group (n=136) and non-alcoholism group (n=470) was 54.0 and 74.0 months ,respectively (Log-rank test: P = 0.045); the median disease-free survival (DFS) was 31.0 and 43.0 months (P = 0.261). COX regression model analysis results show that no- isolate type, size of tumor≥5cm, GGT>64 U ml and alcoholism history are affect the HCC patients OS independent risk factors,no-isolate type, size of tumor≥5cm,tumor cut edge<0.5cm and GGT>64 U ml are influence DFS independent risk factors. The prognosis of HCC patients with alcoholism patients after resection is poor. History of alcoholism not influence patients DFS independent risk factors, but history of alcoholism patients inflammatory state clearly, even if alcohol prohibition after the surgery the recurrence rate is higher than no history of alcoholism,affect the prognosis of HCC patients of history of alcoholism.

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Article: Clinical value of homocysteine, cystatin C and FFA levels in patients with ischemic cerebrovascular disease
by Bing Jiang, Lisheng Ren, Shaoyan Zhang, Pan Wang, Kaiqiu Chu
Cancer Cell Research 2015 1(7) 152-155; published online 9 March 2015
Abstract: To investigate the clinical value of combined detection of plasma homocysteine (Hcy), cystatin C (CysC) and free fatty acid (FFA) in patients with ischemic cerebrovascular disease. Hcy, CysC and FFA in 42 patients with transient cerebral ischemic attacks(TIA), in 57 patients with ischemic stroke and 51 normal persons(controls) were detected respectively by circulating enzymatic, immune transmission turbidimetric and enzymatic. In TIA patients, the levels of Hcy 9.29+3.80 umol/L, CysC 0.83+0.16 mg/L, FFA(0.40+0.17) mmol/L were significantly higher than those in controls, which were 7.78+1.79 umol/L, 0.68+0.082 mg/L, 0.35+0.30 mmol/L P<0.05; In ischemic stroke patients, the levels of Hcy 11.52+6.56 umol/L, CysC 0.97+0.27 mg/L, FFA 0.50+0.30 mmol/L were significantly higher than those in controls, respectively(P<0.01). The levels of CysC and FFA in ischemic stroke patients were significantly higher than those in TIA patients (P<0.05), but Hcy levels between the two groups had no significant difference (P<0.05). In TIA patients, there were positive correlation between Hcy and CysC (r=0.607, P<0.01), CysC and FFA(r=0.469, P<0.01); In ischemic stroke patients, Hcy levels correlated positively with CysC levels. Hcy, CysC and FFA may play an important role in the occurrence of ischemic cerebrovascular disease, and the detection of combining Hcy, CysC and FFA may help the diagnosis, the prognosis and monitoring in ischemic cerebrovascular disease.

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Article: Study of cognitive function in ultra-high risk population of schizophrenia
by  Long Qin, Bo Tian 
Cancer Cell Research 2015 1(7) 156-159; published online 9 March 2015
Abstract: To establish the quality standard of Compound Shanzha Granules. Method: The chief components of the preparation, Crataegi Fructus and Cassiae Semen were identified by TLC. The contents of Autrantio-obtusin and Chrysophanol in Cassiae Semen were determined by HPLC. The separation was performed on Agilent SB-C18 (4.6×250mm, 5μm) with acetonitrile-0.1% phosphoric acid as mobile phase for gradient elution. Results: The relevant spots on TLC plates were clear by the blank reference. The contents showed good linearitis in the range of 0.0357~0.3570µg (r=0.9999) for Autrantio-obtusin and 0.0520~0.5200µg (r=0.9999) for Chrysophanol. The average recovery rate was 99.64% for Autrantio-obtusin and 100.18% for Chrysophanol. Conclusions: The established qualitative and quantitative methods are simple, accurate and reproducible, which can be used for the quality control of Compound Shanzha Granules.

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Article: The effect on Tiaoshen Jianwei Decoction to the motility and SP content in gastrointestinal of rat
by Wenzhi Liu, Junyan Li

Cancer Cell Research 2015 1(7) 160-165; published online 9 March 2015

Abstract: To explore the therapeutic mechanism of Tiaoshen Jianwei Tang to functional dyspepsia (FD). Forty rats were randomly divided into four groups (control group, model group, Mosapride group, Tiaoshen Jianwei Decoction group). All of the rats expect for in control group were induced the FD rat models by clasping their tails. The rats were given relevant medicine therapy and deal with them in 14 days. Then observed their pathological sections by HE staining method, measured and calculated the gastric emptying rate and promoting ratio of small intestine of rats, detected SP level in gastrointestinal by enzyme-linked immunosorbent assay (ELISA) method. Compared with the control group, the rate of gastric emptying and promoting ratio of small intestine of rats were decreased (P<0.05) and the SP content in gastrointestinal was decreased obviously (P<0.01) in model group. after treatment with Tiaoshen Jianwei Decoction, the rate of gastric emptying and promoting ratio of small intestine of rats were increased (P<0.05) and the SP content was increased obviously (P<0.01). Tiaoshen Jianwei Decoction group compared with the control group and Mosapride group was not significant difference (P>0.05). Tiaoshen Jianwei Decoction can regulate the levels of SP in gastrointestinal and recover the function of gastrointestinal motility so as to treat FD.

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