Friday, 20. 4. 2018         

Cancer Cell Research (Online ISSN: 2161-2609)

Current Issue

Vol.5 No.19

Article: Polyene Phosphatidylcholine reverses Oxaliplatin resistance in human gastric cancer BGC823/L-OHP cell lines
by Ronghui Yuan
Cancer Cell Research 2018 5(19) 456-463; published online  5  April 2018

Abstract: This study investigated the effect of polyenoic phosphatidylcholine (PPC) on the proliferation and apoptosis of BGC823/L-OHP cells in an attempt to reverse the mechanism of drug resistance in these cells. Cell counting (CCK-8) was performed to test the ability of PPC and Oxaliplatin (L-OHP; 1, 5, 10, 20, 30, 40µg/ml) can inhibit the growth of gastric cancer cell lines BGC823 and BGC823/L-OHP. The IC50 was calculated. PPC promoted the growth of BGC823/L-OHP cells in the range of 0.5–24µM and inhibited cell growth in the range of 48–86µM. The L-OHP IC50 in BGC823 cells was 3.52µg/ml, while in BGC823/L-OHP cells was 28.53µg/ml. The results indicated that BGC823/L-OHP cells had a strong drug resistance (P<0.05). The L-OHP IC50 of BGC823/L-OHP cells treated with 5µmol/L PPC was 6.63µg/ml. Flow cytometry examination showed that PPC promoted apoptosis in BGC823/L-OHP cells. We also examined the expression levels of TLR4, Nanog, and ABCF2 by RT-PCR and Western blot, and determined that PPC can downregulate the expression of TLR4, Nanog and ABCF2 in resistant strains. PPC can increase the sensitivity of human gastric cancer resistant cells to oxaliplatin. Reversing the effect of oxaliplatin resistance, and this reversal occurs with a reduction in the levels of TLR4, Nanog, and ABCF2.

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Review: Indoor air pollution, lung cancer and solutions
by Hongwei Si
Cancer Cell Research 2018 5(19) 464-470; published online  5  April 2018

Abstract: About 90% of our time is spent indoors where we are exposed to chemical and biological contaminants and possibly to carcinogens. These agents are highly associated with the increased rates of nonspecific respiratory and neurologic symptoms, allergies, asthma and lung cancer. We reviewed the sources, health effects and control strategies for these agents, particularly the major carcinogens from contaminated indoor air. While the fundamental approaches including quitting smoking and using natural and healthy building materials are essential of eliminating indoor air contamination, some simple measures such as increasing ventilation in the central heating, ventilation and air-conditioning systemsand daily opening windows may be realistic, convenient and cost-effective ways to improve indoor air quality and health for homeowners.

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Review: Progress of curcumin on esophageal cancer radiotherapy sensitization
by Shengrong Lv, Xinjia He, Yongheng An
Cancer Cell Research 2018 5(19) 471-476; published online  5  April 2018

Abstract: Esophageal cancer is one of the top ten tumors in the world and radiotherapy is an important treatment method. Due to the interference of many factors, increasing theradiotherapy sensitivity of tumor cells has become an important part of the treatment. Curcumin is a traditional Chinese medicine. Many studies showed that curcumin has radiosensitivity by inducing apoptosis, regulating cell cycle, increasing DNA damage in tumor cells and restraining repair in hypoxic cell. The study of radiotherapy sensitivity of curcumin on esophageal cancer will bring a new opportunity for clinical application.

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Review: Association between survivin-31C/G polymorphism and the risk of urinary system cancer: a meta-analysis
by Kefei Mu, Jianwei Du, Zhaoyong Sun, Dawei Zhang, Yanwei Cao, Yong Liu
Cancer Cell Research 2018 5(19) 477-483; published online  5  April 2018

Abstract: As an inhibitor of apoptosis protein, survivin was abundantly expressed in many human malignancies. Although many studies have demonstrated the relationship between the survivin-31C/G (rs9904341) polymorphism and urinary system cancer susceptibility, the conclusions remained controversial. In order to clarify the effects of this polymorphism on the risk of urinary system cancer, a comprehensive meta-analysis was performed. Six databases were searched to identify the eligible studies. Pooled odds ratios (ORs) with 95% confidenceintervals (CIs) were calculated under the allelic, dominant, homozygous, heterozygous and recessive models. The data were analyzed by using the Stata 12.0. Nine case-control studies were included with a total of 2307 cases and 2722 controls. The results indicated that Survivin-31C/G (rs9904341) polymorphism was associated with increased risk of urinary system cancer (OR=1.28 95%CI=1.01-1.62, P=0.039). Stratified analysis by ethnicity (Asian and Caucasian) indicated thatSurvivin-31C/G variants were associated with a significantly increased risk of urinary system cancer in Asian population (OR=1.53 95%CI=1.27-1.85, P<0.001), but associated with a reduced risk of urinary tract cancer in Caucasian (OR=0.29 95%CI=0.13-0.64, P=0.002). This meta-analysis suggested that the Survivin-31C/G (rs9904341) variants increased the urinary system cancer predisposition in Asian population, and reduced the urinary system cancer predisposition in Caucasian.

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