17. 5. 2017   

Chronic Diseases Prevention Review (Online ISSN: 2158-0820)


Current Issue

Vol.1  No.3


Article: Evaluation of clinical analgesic efficacy of dexmedetomidine combined with sufentanil on uterine contraction pain after hysteromyomectomy: a randomized controlled study
by  Yuncong Zhang, Feng Xue, Haichen Chu, Juntao Wang, Xiao Zhang, He Dong
Chronic Diseases Prevention Review 2017 1(3) 1-7; published online 25 May 2017
Abstract: To evaluate the clinical analgesic efficacy of dexmedetomidine combined with sufentanil on uterine contraction pain after transabdominal hysteromyomectomy. 60 cases of patients applied with ASA I or II generalanesthesia in hysteromyomectomy, they are divided into two groups according to randomized double-blind control (n=30): Group S received 0.04ug/(kg•h) of sufentanil, Group Y received 0.025ug/(kg•h) of sufentanil combined with 0.03ug/(kg•h) of dexmedetomidine, both groups received compound use of 8mg Ondansetron and 2.5mg Inapsine, which are diluted into 100ml with normal saline, with background infusion at 2ml/h, PCA dose of 2ml and a 10min lockout interval. PCA pump was immediately connected after theoperation to record the BCS comfort scores, VAS scores, Ramsay sedation scores, effective pressing number within 48h, dose of sufentanil, nausea and vomiting scores, MAP, HR, SPO 2% at 4h(T1), 8h(T2), 16h(T3), 24h(T4) and 48h(T5) and satisfaction of patients within 48h. Compared with Group S, the VAS scores of Group Y at 4h(T1), 8h(T2), 16h(T3), 24h(T4) and 48h(T5) were lower, self-controlled effective pressing number within 48h declined, dose of sufentanil declined, and the possibility of nausea and vomiting rate declined as well (P<0.05), while the comparison of both groups on Ramsay sedation scores at each time point after 48h of operation was not statistically significant (P<0.05). The application of dexmedetomidine in PCIA after transabdominal hysteromyomectomy could decrease the dose of sufentanil, which could decrease the possibility of nausea and vomiting, obviously relieve the degree of uterine contraction pain, as well as promote the degree of comfortand satisfaction of patients.

Open Access Download (free) PDF


Article: Clinical diagnosis and treatment of advanced renal cell carcinoma associated with von Hippel-Lindau syndrome: a rare case report and review of literature
by  Xiangnan Lin, Zhenli Gao, Hairong Jin, Youyi Lu, Yiping Bao, Lei Shi
Chronic Diseases Prevention Review 2017 1(3) 8-11; published online 25 May 2017
Abstract: Investigate the clinical characteristics of advanced renal cell carcinoma associated with von Hippel-Lindau syndrome to improve the clinicians' understanding and reduce the incidence of missed diagnosis and misdiagnosis. Retrospective analysis of clinical data of 1 patient which suffered VHL syndrome complicated with advanced renal cell carcinoma in urology of Yantai Yuhuangding Hospital Affiliated to Qingdao University, review with the literature. Results: This case of patients without renal mass family history, which multiple mass were found in the pancreas and kidney, several Suspicious mass Scattered in Bilateral kidney, one of the mass located in left renal was performed biopsy under the guidance of ultrasound, and the Histological analysis confirmed after operation were left renal clear cell carcinoma. Surgical is obviously not suitable for treatment due to the number of the tumer. Therefore sunitinib has been used as molecular targeted drug to treatment in 2 years, and regular Computed tomography (CT) scan found the tumor was significantly reduced in follow-up period. VHL syndrome can occur in multiple systems, renal cell carcinoma is a common cause of late death, accurate clinical diagnosis and treatment, can improve the late survival rate of patients with VHL syndrome.

Open Access Download (free) PDF


Article: Malignant hypertension as the initial symptoms in a patient with mesangioproliferative glomerulonephritis: a case report and review the literature
by  Shilei Qiu, Jing Cui, Wenna Li, Huiming Ma, Wenxia Han, Yan zhang
Chronic Diseases Prevention Review 2017 1(3) 12-15; published online 25 May 2017
Abstract: Some patients, especially the type 2 MPGN could have malignant hypertension, but type 1 MPGN patient who have Malignant hypertension were seldom reported. A 16-year-old man was admitted to our hospital with a known history of hypopsia for abnormal vision loss and decrease in renal function. Renal pathology hint of primary membrane proliferative glomerulonephritis. The clinical manifestations of patients with malignant hypertension and renal insufficiency. Patients with clinical symptoms were significantly relieved when given anti-infective, antihypertensive therapy. Kidney Essential Hypertension is the most common secondary hypertension, accounting for the second most common cause of hypertension in adults. To the first manifestations of malignant hypertension as the primary MPGN is rare, in the course of treatment should be based on the control of blood pressure on the active treatment of primary disease.

Open Access Download (free) PDF


Article: Effects and mechanism of neuregulin on oxidative stress injury and Nrf2-are signaling pathway in Ratintracerebralhemorrhage
by  Qiang Liu, Haiping Wang, Wenjing Yan, Yan Song, Yuling Qiao, Shuqing Wang
Chronic Diseases Prevention Review 2017 1(3) 16-21; published online 25 May 2017
Abstract: To investigate the effect of neuregulin (NRG-1β) on neurological function and cerebral edema in rats with intracerebral hemorrhage and to explore the mechanism of neuregulin in intracerebral hemorrhage by detecting the expression of Nrf2-ARE, an endogenous antioxidant pathway. Method: Ninety adult male SD rats were randomly divided into control group, ICH group, ICH+vehicle group and ICH+NRG-1β group (2ug/Kg), and the rat model of intracerebral hemorrhage was established by stereotaxic caudate nucleus injected with type Ⅳ collagenase. After 24 hours of operation, the neurological dysfunction and the brain water content were measured and the expression of Nrf2 and HO-1 protein was detected by immunohistochemistry in every group. Results: Compared with the ICH group, the neurological score and the degree of cerebral edema were significantly reduced in the NRG-1β group after intracerebral ICH. The expression of Nrf2 and HO-1 protein in NRG-1β treatment group was significantly higher than that in ICH group. Conclusion: Neuregulin can significantly reduce the secondary damage of ICH, and its mechanism may be through the activation of Nrf2-ARE antioxidant pathway inducing the expression of downstream antioxidant enzymes, detoxification enzymes to protect nerve cells.

Open Access Download (free) PDF


Article: Analysis of correlation of liver, kidney and thyroid functions with hyperlipidemia in senile patients
by  Yuanyuan Zhang, Song Hu, Jianya Liu, Jie Liu, Lei Zhang, Renping Wang, Yongjun Mao
Chronic Diseases Prevention Review 2017 1(3) 22-27; published online 25 May 2017
Abstract: The objective of this study is to analyze the correlation of liver, kidney and thyroid functions with hyperlipidemia in senile patients, and provide objective clinical data for designing effective treatment plan in clinical work. According to the principle of informed consent form, a number of 1289 senile dyslipidemia patients who did physical examination in the health examination center in our hospital were enrolled in the study. Questionnaire of blood lipid was used to investigate general information of senile patients with dyslipidemia; indicators related to blood lipid, liver function, renal function and thyroid function were tested and factors related to dyslipidemia were analyzed. Statistical analysis demonstrated that the morbidity rate of high level of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in female was higher than that in male and the prevalence rate of low level of high density lipoprotein cholesterol (HDL-C) in male was higher than that in female, which were all statistically significant; there was no significant difference of triglyceride (TG) levels between male and female. High TC, TG and LDL-C was mainly concentrated in the 66-70 years of age; while, there was no obvious difference of the prevalence rate of low HDL-C among different ages.TC was positively correlated with ALT, GGT and UA; TG was positively associated with age, ALT, GGT and UA; HDL-C was negatively correlated with sex and UA; LDL-C was positively associated with Cr and UA, and negatively correlated with sex and ALT. Therefore, the morbidity of dyslipidemia could be effectively decreased by improving liver function, renal function and thyroid function.

Open Access Download (free) PDF


Article: Quantitative structure-activity relationships of 5-HT2C agonists with obesity
by   Longyang Li, Xiaolin Wu, Chensheng Qiu, Xuexiao Ma, Bohua Chen
Chronic Diseases Prevention Review 2017 1(3) 28-33; published online 25 May 2017
Abstract: Gene expression programming (GEP) as a novel machine learning technique was firstly used to predict the EC50 of 5-HT2C agonist. Each kind of compound was represented by a series of calculated structural descriptors. GEP model is based on five descriptors which were selected from the descriptors’ pool by heuristic method (HM) to build multivariable linear model. As a remarkable result, the GEP method generated a nonlinear quantitative model with a correlation coefficient and a variance of 0.82 and 0.10 for the training set, 0.78 and 0.18 for the test set, respectively. It indicates that GEP can be applied to study the 5-HT2C agonist, and the predicted results are well consistent with experimental values.

Open Access Download (free) PDF


 
��ҳģ��