25. 9. 2021   

Chronic Diseases Prevention Review (Online ISSN: 2158-0820)


Current Issue

Vol.5  No.18


Article: Effects of fluoxetine on mood, cognition and neurogenesis along the septo-temporal axis of hippocampus in antidepressants-resistant rats after ischemic stroke
by Xiaotian Gao, Jiexin Zhao, Feng Gao, Jin Xie, Fei Liu, Luoyi Shi
Chronic Diseases Prevention Review 2021 5(18) 1-7; published online  19 September2021
Abstract: Stroke induces mood and cognitive impairments, about 30% of which are antidepressants-resistant. To investigate the evidence and related molecular mechanisms of fluoxetine on fluoxetine-resistant sedentary ischemic stroke rats. Wistar rats after middle cerebral artery occlusion/reperfusion were randomly divided into Sham, Sedentary, fluoxetine-effective (Flu-E), fluoxetine-resistant (Flu-R) groups. The behavioral tests (open field test for anxiety, and delayed non-matching to place task for spatial pattern separation) were performed before and after intervention. We investigated regional changes in neurogenesis by immunohistochemical staining for doublecortin (DCX) and brainderived neurotrophic factor (BDNF) in the dorsal dentate gyrus (dDG) and ventral DG (vDG). The depression behaviors with pattern separation deficit and impaired hippocampal neurogenesis in the dDG were found in the fluoxetine-resistant sedentary cerebral ischemic rats. Fluoxetine significantly increased the BDNF and DCX expression level in the both dDG and vDG in the fluoxetine-effective rats, while there was no significant difference in fluoxetine-resistant group. Traditional antidepressants for treating depressive disorders with cognitive deficits have limited efficacy. It is necessary to explore the region-specific effects of stress on neurogenesis and region-specific changes in cognitive and emotional behaviors along the septo-temporal axis of hippocampus.

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Article: Effects of exercise on depression and hippocampal neurogenesis in the post stroke depression rats
by  Luoyi Shi, Feng Gao, Bao Zhang, Fei Liu, Song Yuan, Xiaotian Gao
Chronic Diseases Prevention Review 2021 5(18)8-13; published online   1 September 2021
Abstract: Stroke induces mood impairments, about 30% of which are antidepressants-resistant. To investigate the evidence and related molecular mechanisms of physical exercise on post stroke depression (PSD) rats. Wistar rats after middle cerebral artery occlusion/ reperfusion and chronic unpredictable mild stress were randomly divided into Sham, PSD and physical exercise groups. The behavioral tests (sucrose preference test for depression, open field test for anxiety) were performed before and after intervention. We investigated regional changes in neurogenesis by Nissl staining, western blotting and immunohistochemical staining for BDNF, doublecortin (DCX) in the dentate gyrus (DG). The depression/anxiety-like behaviors and impaired hippocampal neurogenesis in the DG were found in PSD rats. Physical exercise intervention reversed both depression/anxiety-like behaviors, increase the expression of DCX, BDNF in the DG. Physical exercise could be a viable adjunctive strategy in combination with antidepressants as an effectively protective intervention for PSD rats, might via increasing neurogenesis in DG.

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