25. 4. 2019   

Chronic Diseases Prevention Review (Online ISSN: 2158-0820)


Current Issue

Vol.3  No.10


Article: Protective effect of hydrogen sulfide on articular cartilage
by  Xianan Li, Shaoqi Tian, Yuanhe Wang, Jiangjun Liu, Tao Ding, Guoqing Chu, Kang Sun
Chronic Diseases Prevention Review 2019 3(10) 1-6; published online  18 April  2019
Abstract:  To investigate the effect of H2S on articular cartilage degeneration in rabbit knee osteoarthritis model and to explore the protective effect of H2S on osteoarthritis. Thirty-two New Zealand white rabbits were randomly divided into four groups: blank control group, OA model group, H2S intervention group and H2S inhibition group, with 8 rabbits in each group. Group A was not treated. Group B, C and D were injected with saline, NaHS diluent and H2S inhibitor 1 ml each into the knee joint cavity once a week for 6 weeks to establish OA model. Animals were sacrificed 7 weeks after operation. Articular cartilage was taken for HE staining, and scored according to Mankin's method. The expression of collagen type II in cartilage was detected by immunohistochemistry, and the expression of MMP-1, MMP-3 and MMP-13 in cartilage was detected by Real-time PCR. Mankin's score showed that the scores of group B, C and D were higher than those of group A (P<0.05). The scores of group C were lower than those of group B, and the scores of group D were higher than those of group B (P<0.05). Type II collagen staining showed that compared with group A, the positive staining of type II collagen in group B was significantly lower and unevenly distributed; the positive staining of type II collagen in group C was higher than that in group B; the positive staining of type II collagen in group D was significantly lower and the superficial layer was defective (P<0.05). Compared with group B, the expression of MMP-1, MMP-3 and MMP-13 in articular cartilage decreased in group C, and increased in group D compared with group B (P<0.05). H2S can inhibit the expression of MMP-1, MMP-3 and MMP-13 in articular cartilage, reduce the degradation of collagen II in articular cartilage, and protect articular cartilage in osteoarthritis.

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Article: Evaluation of right ventricular systolic function in patients with chronic renal insufficiency with 3D-STI
by  Yingtao Li, Rong Zhang, Weigang Liu, Lan Ma, Rong Li, Yan Zhu, Dongmei Sun
Chronic Diseases Prevention Review 2019 3(10) 7-10; published online 18 April  2019
Abstract:  To evaluate the clinical value of 3D-STI in the evaluation of right systolic function in patients with chronic renal insufficiency. 34 patients with mild chronic renal insufficiency (CKD1-2 group), 44 patients with moderate to severe chronic renal insufficiency (CKD3-5 group), who accepted treatment in the West Coast of Qingdao University Affiliated Hospital from January 2016 to May 2018, and 41 healthy volunteers (control group) were enrolled. 3D-STI analysis was underwent, and the indicators, including right ventricle end-systolic volume (RVESV), right ventricle end-diastolic volume (RVEDV), three-dimensional right ventricular ejection fraction (3D-RVEF), right ventricular longitudinal strain (RVGLS) and right ventricular free wall longitudinal strain (RVFLS) were compared. Compared with the normal group, the RVEDV and RVESV in the mild group increased, while the 3D-RVEF, RVCLS, and RVFLS decreased (P>0.05). Compared with the normal group and the mild group, the RVESV and RVESV were significantly increased in the moderate to severe group, while 3D-RVEF, RVCLS, and RVFLS were significantly decreased with the statistically significant difference (P<0.05). It could be concluded that 3D-STI can detect changes in right ventricular systolic function in patients with renal insufficiency and provide valuable information for clinical treatment.

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Article: Correlation between coronary slow flow phenomenon and Cystatin C
by  Mengwan Li, Zhexun Lian, Lu Han, Kai Tan
Chronic Diseases Prevention Review 2019 3(10) 11-14; published online 18 April  2019
Abstract:  Our study was to investigate the factors relating to the coronary slow flow phenomenon (CSFP) and to observe the changes of Cystatin C (CysC) level in patients with coronary slow flow phenomenon (CSFP) and clinical predictive value. The CysC levels were examined. The data of patients with coronary angiography were collected. The proportion of male in the CFSP group was significantly higher than the other two groups (p<0.05). The age and creatinine level were significantly lower than the other two groups (p<0.05). The level of cystatin C, uric acid and proportion of smoking history in patients with CSFP was higher than that in normal group and lower than that in mild stenosis group (p<0.05). Cystatin C was an independent risk factor for CSFP (OR>1), while uric acid and history of smoking are not related to CSFP. In the CSFP group, LAD, LCX and appears RCA were 75.36%, 68.12% and 23.91%, respectively. There were no significant differences in gender, age, cystatin C, UA, CREA, UREA, and smoking history among the different vessels in the CSFP group (P>0.05). Serum cystatin C level is associated with the occurrence and development of CSFP, and it can be the predictor of CSFP.

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Article: Research status of alcohol consumption and obesity
by  Xiang Xu, Shaojie Wang
Chronic Diseases Prevention Review 2019 3(10) 15-20; published online 18 April  2019
Abstract:  Obesity has become a common disease. According to the data reported in 2010, the prevalence of central obesity above 18 years old was 30%-40%. Obesity not only is a serious chronic disease, but also increases the morbidity and mortality of some diseases, such as cardiovascular disease, diabetes, cancer and musculoskeletal disorders. In male, most studies have demonstrated that alcohol consumption is associated with obesity, and those studies have rendered a J-shaped dose-response trend; in female, most studies have suggested that it is no association or inverse association. The conclusion of drinking different categories is slightly different. Beer is a risk factor for central obesity; some studies have suggested that it’s a J-shaped relationship between wine consumption and body mass index (BMI); there is a linear correlation between spirits and obesity. Some studies have thought that alcohol consumption is a U-shaped relationship between obesity, and heavy drinking is a risk factor for obesity, and moderate drinking is recommended. At present, there is no consistent conclusion on the relationship between alcohol consumption and obesity.

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Article: The Effects of nutraceutical combinations based on red yeast rice supplementation on cholesterol Levels in adults
by  Huimin Cheng, Hui Liang
Chronic Diseases Prevention Review 2019 3(10) 21-24; published online 20 April  2019
Abstract:  Red yeast rice (RYR) is the fermented functional food with Monacus purpureus onto rice. It includes a multitude of bioactive components monacolins, polyketide pigments, and unsaturated fatty acids. The bioactive ingredient monacolin K of red yeast rice is similar to the synthetic drug lovastatin but has no serious side effects of statins. This mini-review summarizes the effects of RYR on cholesterol levels in patients with hyperlipidemia and statin intolerance.

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Article: Risk factors related to hypertension in tuberculosis patients
by  Boyang Wei, Qian Liu, Chunjiang Dong, Baoli Du, Tingyan Kou, Jiaqi Song, Qiuzhen Wang
Chronic Diseases Prevention Review 2019 3(10) 25-30; published online 29 April  2019
Abstract:  Tuberculosis and high blood pressure are two major diseases that affect human health. According to the WHO survey, tuberculosis is the ninth cause of death in the global. Nearly a quarter of the world's population suffers from high blood pressure, and hypertension has become an independent factor in the death of certain diseases such as stroke and ischemic heart disease. This article mainly discusses the risk factors of hypertension in pulmonary tuberculosis patients, and provides a scientific basis for the early detection and prevention of hypertension in tuberculosis patients. A total of 100 patients with tuberculosis were enrolled in the study, 9 of them had hypertension. Patient data were collected by querying medical records and questionnaires. Logistic regression analysis was used to analyze the risk factors of pulmonary tuberculosis patients with hypertension. The distribution of Age and BMI in patients with hypertension and normal blood pressure was statistically significant. Univariate logistic regression analysis showed that age 50 years (OR (95% CI), 8.640(1.079-76.251)) and BMI 24 (OR (95% CI), 4.766(1.146-19.822)) were the risk factors for pulmonary tuberculosis with hypertension (P<0.05), while Multivariate logistic regression analysis showed that only BMI ³ 24 (OR (95% CI), 4.766(1.146-19.822)) was the risk factor for pulmonary tuberculosis with hypertension (P<0.05). We found that the prevalence of hypertension in tuberculosis patients is higher, and the risk factors for hypertension are overweight/obese. Elderly age may also be the risk factor of hypertension in tuberculosis patients, which need a further study expanding the sample.

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Article: A comparative analysis of simultaneous and staging total knee arthroplasty in one hospitalization cycle
by  Tao Ding, Shaoqi Tian, Jiangjun Liu, Xianan Li, Guoqing Chu, Kang Sun
Chronic Diseases Prevention Review 2019 3(10) 31-35; published online 29 April  2019
Abstract:  To evaluate the efficacy and safety of bilateral TKA in patients with knee osteoarthritis (KOA) during one hospitalization cycle. Bilateral knee osteoarthritis in 56 patients studied retrospectively. 30 patients underwent bilateral TKA operation as control group, 26 patients underwent bilateral TKA operation as observation group by stages. The preoperative general condition, intraoperative condition, postoperative recovery and incidence of complications were compared and analyzed among the two groups. No significant differences have been observed in age, sex composition, BMI and NNIS scores in the two groups before operation (P>0.05); No significant differences have been observed in joint activity, HSS score, VAS score and complications in the two groups after operation (P>0.05); The observation group showed a shorter operative time and postoperative hospital stay, and the medical cost was lower in the observation group when compared with the control group (P<0.05). The blood loss and transfusion, however, were significantly higher in the observation group when compared with the control group (P<0.05). For first-time patients underwent bilateral total knee arthroplasty, there was no statistically significant in safety and effectiveness between the observation group and control group under strict perioperative management and careful evaluation. However, the observation group has the advantages of short total operation time and postoperative hospital stay, economical applicability and quick postoperative recovery, and thus deserving popularization.

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Article: Study on the effect of smoking on the risk of active pulmonary tuberculosis in patients with type 2 diabetes mellitus
by  Chunjiang Dong, Tingyan Kou, Yufeng Liu, Yue Zou, Limei Sun, Hong Tian, 
       Boyang Wei, Qian Liu, Yuze Mu, Xuezhao Lu, Qiuzhen Wang
Chronic Diseases Prevention Review 2019 3(10) 36-41; published online 29 April  2019
Abstract:  To investigate the effect of smoking on the risk of active pulmonary tuberculosis (PTB) in patients with type 2 diabetes mellitus (DM). Using a case control study design matched with 1:2, the newly diagnosed patients with active pulmonary tuberculosis and type 2 diabetes mellitus (DM-PTB) in a municipal hospital from January 2017 to January 2018 were selected as the case group. At the same time, the patients with simple DM were treated in a municipal general hospital as the control group. The patients in two hospitals who met the inclusion criteria were surveyed by specially trained investigators using a unified questionnaire, and the patients were measured by physiometric measurements and related laboratory tests. A total of 315 subjects were included in this study, including 105 cases with DM-PTB in the case group and 210 cases with DM in the control group. According to the distribution of smoking, the proportion of smokers in the case group was significantly higher than that in the control group (P<0.001). Multivariate conditional Logistic regression analysis showed that poor glycemic control, tuberculosis (TB) exposure history and smoking were risk factors for active PTB in DM patients. Compared with nonsmokers, current smokers (OR, 95% CI: 12.194, 3.527, 42.162) and former smokers (OR, 95% CI: 4.591, 1.073, 19.638) had significantly higher risk of active PTB, and the increased risk of current smokers was more obvious. Smoking is an independent risk factor for active pulmonary tuberculosis in patients with type 2 diabetes mellitus.

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