25. 3. 2018         

Chronic Diseases Prevention Review (Online ISSN: 2158-0820)


Current Issue

Vol.2 No.7


Article: The relationship between PCT and CRP and premature rupture of membranes and intrauterine infection is less than 34 weeks
by  Yuannan Diao
Chronic Diseases Prevention Review 2018 2(7) 1-4; published online 25 May  2018
Abstract:  To investigate the relationship between PCT and C reactive protein (CRP), and to investigate the time of premature rupture of membranes and intrauterine infection less than 34 weeks. 234 cases of <34 weeks preterm infants were collected in the Department of Obstetrics. All patients were divided into group A (52) without premature rupture of fetal membranes, group B of PROM<48h premature infant (84), group C of PROM 49-168h (59), and group D of PROM>168h (39), respectively. The infection index of prenatal and postnatal children was collected. The difference of the positive rate of intrauterine infection and the difference of infection index between pregnant women and their pregnant women were compared. The difference of C reactive protein of antenatal infection index of pregnant women was statistically significant (P<0.05). But it did not increase with the prolongation of membrane breaking time. The longer the time of rupture of the membrane, the higher the PCT value of the sick children (P<0.05). The longer fet al membrane breaks, the higher the incidence of HCA, the incidence of HCA, and the incidence of HCA. There was a significant difference in the incidence of HCA between the 4 groups (P<0.05). Prenatal and neonatal blood PCT and CRP are sensitive indicators for early prediction of premature rupture of membranes and placental chorioamnionitis.

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Article: Effect and mechanism of fucoidan on VEGF in atherosclerotic oxidative stress signal pathway
by Jie Xu, Yingjie Xu, Lei Gao, Jun Zhao
Chronic Diseases Prevention Review 2018 2(7) 5-10; published online 25 May 2018
Abstract: To investigate the effects and mechanisms of fucoidan sulfate (Fucoidan) on VEGF in atherosclerotic (AS) oxidative stress signaling pathway of apolipoprotein E deficient mice. The healthy male Kunming mice(n=10) and absence of ApoE gene (ApoE-/-) mice (30) were chosen and randomly divided into 4 groups: blank control group, Fucoidan treatment group, (ApoE-/-) negative AS group and the (ApoE-/-) the negative control group. The effects of Fucoidan on lipid metabolism and AS plaques in model animals were observed by using ELASA kit which helps to detect blood biochemical indexes in the peripheral blood of the AS model. Using HE staining, oil red O staining, and immunohistochemistry methods to detect the expression of vascular endothelial growth factor (VEGF) in oxidative stress signal pathway. The blank control group, Fucoidan treatment group, ApoE (-/-) AS model group were compared with the negative control group. 4 group animal blood biochemical indexes in peripheral blood were tested. The total cholesterol, triglyceride and other indexes of Fucoidan treatment group was compared with the AS model control group (P<0.05). Low density lipoprotein cholesterol levels increased significantly (P<0.05). HE staining and oil red O staining showed that the size of atherosclerotic plaques in the Fucoidan treatment group was significantly smaller than that of the ApoE (-/-) AS model group (P<0.05). Immunohistochemistry result showed that the level of Fucoidan in the treatment group with the ApoE VEGF was significantly higher than that of AS model group (P<0.05). Fucoidan in brown fat can decrease total cholesterol and triglyceride levels in the peripheral blood, improve the level of LDL cholesterol, reduce the formation of atherosclerotic plaque, enhance oxidative stress signaling pathways in the related factor, protein expression.

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