Chronic Diseases Prevention Review (Online ISSN: 2158-0820)
Current Issue
Vol.2 No.7
Article: The relationship between PCT and CRP and premature rupture of membranes and intrauterine infection is less than 34 weeks
by Yuannan Diao
Chronic Diseases Prevention Review 2018 2(7) 1-4; published online 25 May 2018
Abstract: To
investigate the relationship between PCT and C reactive
protein (CRP), and to investigate the time of premature
rupture of membranes and intrauterine infection less than 34
weeks. 234 cases of <34 weeks preterm infants were collected
in the Department of Obstetrics. All patients were divided
into group A (52) without premature rupture of fetal
membranes, group B of PROM<48h premature infant (84), group
C of PROM 49-168h (59), and group D of PROM>168h (39),
respectively. The infection index of prenatal and postnatal
children was collected. The difference of the positive rate
of intrauterine infection and the difference of infection
index between pregnant women and their pregnant women were
compared. The difference of C reactive protein of antenatal
infection index of pregnant women was statistically
significant (P<0.05). But it did not increase with the
prolongation of membrane breaking time. The longer the time
of rupture of the membrane, the higher the PCT value of the
sick children (P<0.05). The longer fet al membrane breaks,
the higher the incidence of HCA, the incidence of HCA, and
the incidence of HCA. There was a significant difference in
the incidence of HCA between the 4 groups (P<0.05). Prenatal
and neonatal blood PCT and CRP are sensitive indicators for
early prediction of premature rupture of membranes and
placental chorioamnionitis.
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Article: Effect and mechanism of fucoidan on VEGF in atherosclerotic oxidative stress signal pathway
by Jie Xu, Yingjie Xu, Lei Gao, Jun Zhao
Chronic Diseases Prevention Review 2018 2(7) 5-10; published online 25 May 2018
Abstract:
To investigate the effects and mechanisms of fucoidan
sulfate (Fucoidan) on VEGF in atherosclerotic (AS) oxidative
stress signaling pathway of apolipoprotein E deficient mice.
The healthy male Kunming mice(n=10) and absence of ApoE gene
(ApoE-/-) mice (30) were chosen and randomly divided into 4
groups: blank control group, Fucoidan treatment group,
(ApoE-/-) negative AS group and the (ApoE-/-) the negative
control group. The effects of Fucoidan on lipid metabolism
and AS plaques in model animals were observed by using ELASA
kit which helps to detect blood biochemical indexes in the
peripheral blood of the AS model. Using HE staining, oil red
O staining, and immunohistochemistry methods to detect the
expression of vascular endothelial growth factor (VEGF) in
oxidative stress signal pathway. The blank control group,
Fucoidan treatment group, ApoE (-/-) AS model group were
compared with the negative control group. 4 group animal
blood biochemical indexes in peripheral blood were tested.
The total cholesterol, triglyceride and other indexes of
Fucoidan treatment group was compared with the AS model
control group (P<0.05). Low density lipoprotein cholesterol
levels increased significantly (P<0.05). HE staining and oil
red O staining showed that the size of atherosclerotic
plaques in the Fucoidan treatment group was significantly
smaller than that of the ApoE (-/-) AS model group (P<0.05).
Immunohistochemistry result showed that the level of
Fucoidan in the treatment group with the ApoE VEGF was
significantly higher than that of AS model group (P<0.05).
Fucoidan in brown fat can decrease total cholesterol and
triglyceride levels in the peripheral blood, improve the
level of LDL cholesterol, reduce the formation of
atherosclerotic plaque, enhance oxidative stress signaling
pathways in the related factor, protein expression.
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