Chronic Diseases Prevention Review (Online ISSN: 2158-0820)
Current Issue
Vol.2 No.5
Article: Clinical research of collateral circulation in patients with severe internal carotid artery stenosis
by Chongwen Zheng, Hongyun Li
Chronic Diseases Prevention Review 2018 2(5) 8-12; published online 5 January 2018
Abstract:
To observe the relationship between collateral circulation
with cerebral infarction and neurological deficit in
patients with severe internal carotid artery stenosis. 108
patients were selected who are unilateral internal carotid
artery severe stenosis and were compared the incidence of
cerebral infarction and type of infarction and NIHSS score.
Among the 108 patients, 54 patients were first collateral
circulation, while 20 patients were cerebral infarction.
35 patients were secondary collateral circulation, while
25 patients were cerebral infarction. 19 patients were without
cerebral infarction, while 17 patients were cerebral
infarction. The difference of collateral circulation has
statistically significant (P<0.01). The difference of
cerebral infarction type caused by different collateral
circulation was not statistically significant (P<0.01).
Neurological function scores of patients were statistically
significant who were different collateral circulation
(P<0.01). There were significant differences in the
incidence of cerebral infarction, the type of cerebral
infarction and the neurological deficit of the patients with
different collateral circulation. There was obvious in
protective effect of cerebral collateral circulation on the
brain.
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Article: Predictive value of preoperative systemic immune-infammation index on tumor stage in patients with colorectal cancer
by Yong Tao, Guangen Yang, Jianming Qiu, Xiujun Liao, Weiming Mao, Changjian Wang, Dong Wang,
Hongtao Wang, Chao Fu
Chronic Diseases Prevention Review 2018 2(5) 13-18; published online 25 January 2018
Abstract:
The aim of this study was to demonstrate the clinical
significance of the preoperative neutrophil-to-lymphocyte
ratio (NLR) and platelet to lymphocyte ratio (PLR) in
association with tumor stage of colorectal cancer (CRC)
patients. We undertook a retrospective review of 144
patients with colorectal cancer. Preoperative whole blood
counts, serum levels of carcinoembryonic antigen (CEA),
carbohydrate antigen (CA-199), and clinicopathologic data
were collected. The correlations between laboratory
parameters and the tumor, node, and metastasis (TNM) stages
were analyzed. ROC analysis indicated that both NLR (0.79)
and PLR (0.64) had the comparable predictive powers for the
presence of CRC in the general patient group. Kruskal-Wallis
analysis revealed that significant elevations of NLR
(P=0.0018) was firstly detected in all stages and showed a
stage-dependent increase following the development of T, M
stage (all P<0.05), while PLR was only identified as an
independent factor for the T stage development (P<0.05).
Accordingly, NLR and PLR was also identified as an
independent factor associated with tumor grade (all P<0.05)
by the univariate and multivariate regression analysis
model. Thus, our data indicated that both neutrophil-and
platelet-mediated inflammatory reactions are predominantly
involved in the different stages of CRC development.
Determination of pretreatment levels of NLR and PLR might
provide useful information for the early diagnosis or the
therapeutic choices in CRC patients.
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Article: miRNA-375 regulates the invasion and metastasis of human lung cancer A549 cells by targeting EMT
by Junyu Wu, Haining Meng, Liping Liang, Qiao Huang, Jiawei Huang,
Yixuan Luo, Xuekun He, Shengwei Xu, Ruowu Shen
Chronic Diseases Prevention Review 2018 2(5) 19-24; published online 25 January 2018
Abstract:
To investigate whether abnormally high expression of
miRNA-375 is associated with epithelial cell mesenchymal
transition (EMT) in lung cancer cells. The stable
overexpression cell line was constructed by lentivirus and
transfected into empty vector as a control group. The
expression of miRNA-375 was detected by real-time
fluorescence quantitative PCR. The protein expression of
EMT-related protein E-cadherin and Vimentin were detected in
three groups of cells by western blot. The cell invasion and
metastasis were evaluated by transwell methods and wound
healing. EMT of lung cancer A549 cells was characterized by
mesenchymal cell cytoskeleton and morphology, and the
expression of EMT-related marker protein E-cadherin was down
regulated while the expression of Vimentin was up regulated.
Transwell methods and wound healing showed that aberrant
expression of miRNA-375 in A549 cells was significantly
increased (P<0.05). The abnormal expression of microRNA-375
is associated with EMT in lung cancer A549 cells.
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Article: Research of the concentration of ropivacaine for postoperative analgesia in the knee joint
by Xianglin Ji, Jihui Yin, Xiaojun Ma, Hui Huang, Aihua Jiang
Chronic Diseases Prevention Review 2018 2(5) 25-29; published online 25 February2018
Abstract:
To observe the effect of different concentration of
ropivacaine that were used for sciatic nerve and femoral
nerve block on postoperative muscle strength recovery and
postoperative pain after the total knee arthroplasty under
the ultrasonic guidance. 90 patients who had undergone
unilateral TKA were randomly divided into the group Q, the
group W, the group E (n=30). The patients of the three
groups were treated with different concentration of
ropivacaine 20ml (the group Q, 0.35%, the group W, 0.375%,
the group E, 0.4%) for sciatic nerve block, and 0.4%
ropivacaine 20ml were performed femoral nerve block. The
heart rate, blood pressure and mean arterial pressure were
observed during the operation to evaluate the analgesic
effect. The patient's pain was assessed by visual analogue
scale (visual, analogue, score, VAS). The ankle pump
movement was used Score of hospital for special surgery (HSS
score) to assess the recovery of muscle strength after the
operation. The group Q’s data shows a higher postoperative
pain score than the others (VAS≥4 score) and the muscle
strength recovers quickly than the others (T≤24h). The
postoperative pain score of the group W and the group E are
lower than group Q (VAS≤4 score). The group W that the
recovery of motor function is earlier (≤24h), but the
recovery of motor function of the group E costs much time
(≥24h). There is no statistical significance that is Age,
gender, height, American Society of Anesthesiology (ASA) and
weight in the three groups (p>0.05). The difference is
statistically significant that is the ankle pump movement of
time and VAS of the three groups (p<0.05). From the point of
view of analgesia, the group W and the group E are suitable
for TKA (VAS≤4 score), but the time that is the recovery of
motor function of 0.4% ropivacaine is longer than the others
(T≥24h). From the point of view of the time of muscle
recovery, the group Q and the group W are fit. But the group
Q has higher VAS scores than the others (VAS≥4 score). Not
only does it reduce the patient's postoperative pain, but
little affects the patient's early functional exercise.
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