25. 7. 2020   

Chronic Diseases Prevention Review (Online ISSN: 2158-0820)

Current Issue

Vol.4  No.15

Article: Research progress of CRISPR-Cas system application
by  Miaoyu Liu
Chronic Diseases Prevention Review 2020 4(15) 1-4; published online  5 July 2020
Abstract: The CRISPR-Cas system is an adaptive immune defense system found in the genomes of 45% bacteria and most archaea in recent years, which can effectively resist the invasion of foreign genetic elements. In recent years, the CRISPR-Cas system has been used in many fields, such as gene editing, gene therapy, bacterial typing and evolution research.

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Article: The effects of high-intensity interval training in prevention and treatment of depression and anxiety: a systematic review and meta-analysis
by  Chenggang Wu, Feng Gao, Song Yuan, Luoyi Shi, Peng Wang, Fei Liu
Chronic Diseases Prevention Review 2020 4(15)5-20; published online  15 July 2020
Abstract: To assess the effects of high-intensity interval training (HIIT) in reducing or preventing depression or anxiety. A systematic electronic searching of the PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, SPORTSDiscus, PsycINFO, SCOPUS and CINAHL (EBSCOhost) was initially performed up to 5 December 2019. Randomized controlled trials (RCTs) were included if they contained data on depression and/or anxiety outcomes taken pre and post HIIT treatment. Data were extracted by 2 independent coders. Estimates were examined by using random-effects meta-analysis Fourteen independent samples (493 participants) were included. There was a statistical significant reduction in depression symptom following HIIT compared with both continuous training (CT) and control conditions (CON) (HIIT vs. CT: standardized mean difference [SMD]=-0.35, 95% confidence Interval [CI] -0.66 to -0.04, P=0.025; CON: SMD=−0.49, 95% CI −0.92 to −0.07, P=0.022). There were no statistically significant differences between groups in anxiety symptom (HIIT vs. CT: SMD=-0.45, 95% CI -1.11 to 0.21, P=0.182; CON: SMD=-0.14, 95% CI -0.47 to 0.18, P=0.386). HIIT is associated with decreased concurrent depressive symptoms; the association with anxiety symptoms is weak.

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