25. 8. 2020   

Chronic Diseases Prevention Review (Online ISSN: 2158-0820)


Current Issue

Vol.4  No.15


Article: Research progress of CRISPR-Cas system application
by  Miaoyu Liu
Chronic Diseases Prevention Review 2020 4(15) 1-4; published online  5 July 2020
Abstract: The CRISPR-Cas system is an adaptive immune defense system found in the genomes of 45% bacteria and most archaea in recent years, which can effectively resist the invasion of foreign genetic elements. In recent years, the CRISPR-Cas system has been used in many fields, such as gene editing, gene therapy, bacterial typing and evolution research.

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Article: The effects of high-intensity interval training in prevention and treatment of depression and anxiety: a systematic review and meta-analysis
by  Chenggang Wu, Feng Gao, Song Yuan, Luoyi Shi, Peng Wang, Fei Liu
Chronic Diseases Prevention Review 2020 4(15)5-20; published online  15 July 2020
Abstract: To assess the effects of high-intensity interval training (HIIT) in reducing or preventing depression or anxiety. A systematic electronic searching of the PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, SPORTSDiscus, PsycINFO, SCOPUS and CINAHL (EBSCOhost) was initially performed up to 5 December 2019. Randomized controlled trials (RCTs) were included if they contained data on depression and/or anxiety outcomes taken pre and post HIIT treatment. Data were extracted by 2 independent coders. Estimates were examined by using random-effects meta-analysis Fourteen independent samples (493 participants) were included. There was a statistical significant reduction in depression symptom following HIIT compared with both continuous training (CT) and control conditions (CON) (HIIT vs. CT: standardized mean difference [SMD]=-0.35, 95% confidence Interval [CI] -0.66 to -0.04, P=0.025; CON: SMD=−0.49, 95% CI −0.92 to −0.07, P=0.022). There were no statistically significant differences between groups in anxiety symptom (HIIT vs. CT: SMD=-0.45, 95% CI -1.11 to 0.21, P=0.182; CON: SMD=-0.14, 95% CI -0.47 to 0.18, P=0.386). HIIT is associated with decreased concurrent depressive symptoms; the association with anxiety symptoms is weak.

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Article: The application effect of cognitive impairment training in patients with Alzheimer's disease in the early and middle stage
by  Caihong Xue, Furong Sun, Fangyuan Wang, Mingming Hu
Chronic Diseases Prevention Review 2020 4(15)21-24; published online  15 August  2020
Abstract: To explore the application effect of cognitive impairment functional training in patients with early and mid-term Alzheimer's disease and the influence of different training cycles on the application effect. 52 patients with Alzheimer's disease were selected for 4, 8, 12 and 16 weeks of cognitive impairment training (2 training sessions per week for 30-45 min) in the early and middle stages. Self-control was used at the end of each cycle. Simple Mental State Scale (Mini-Mental State Examination, MMSE). Montreal Cognitive Assessment Scale (Montreal cognitive assessment, MoCA). The Lawton and Brody Instrumental Activities of Daily Living (Instrumental Activities of Daily Living, IADL). The cognitive ability and daily living ability of the patients were evaluated, and the evaluation results of each cycle were compared with those when they were enrolled. There were significant differences between MMSE, MOCA and ADL scores and group entry score (P<0.05). Differences in scores between groups were statistically significant (P<0.05). Cognitive impairment training is effective in delaying the progress of Alzheimer's disease in the early and middle stages, and the effect of different training cycles was significantly different, which also plays an important role in improving the quality of life of patients.

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Article: Relationship between caffeine and alcohol intake and osteoporosis
by  Genquan Jin, Jingjing Wang, Xiubo Jiang
Chronic Diseases Prevention Review 2020 4(15)25-31; published online  15 August 2020
Abstract: Osteoporosis is a common bone metabolic disorder that can make people weak. It is characterized by reduced bone density and mass, and is often associated with damaged trabecular bone structures, leading to an increased risk of fracture. The pathogenesis of osteoporosis is complex, and the influencing factors include genetic factors, environmental factors, dietary conditions, poor living habits, etc. Moreover, the risk of osteoporosis also varies among different ages, genders and races. At present, there are few studies on the relationship between caffeine and alcohol intake and osteoporosis at home and abroad, and the conclusions of relevant studies are still controversial. Therefore, this study intends to use the large data set of the National Health and Nutrition Examination Survey to investigate the relationship between caffeine and alcohol intake and osteoporosis, and the results of this study can provide scientific basis for the prevention of osteoporosis in adults.

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Review: A review of post-traumatic stress disorder
by  Linxuan Li
Chronic Diseases Prevention Review 2020 4(15)32-35; published online  25 August 2020
Abstract: With the development of technology and the passage of time, people's material needs have been constantly met, and mental health has become more and more important. In 2020, the coVID-19 pandemic is sweeping the world. In the face of such a serious public health safety incident, people not only pay attention to their own safety issues, but also suffer from stress, trauma and emotional distress. Post-traumatic stress disorder is a kind of reactive mental disorder. With the in-depth research on mental health, the research in this field is also making new achievements. This article summarizes existing research on PTSD from the perspectives of its basic concept, risk factors, cognitive theory, diagnosis and treatment, which can be an important implication for future research in this field.

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Article: Risk of excessive daytime sleepiness in Parkinson’s disease: A meta-analysis
by  Yu Gao, Fengju Jia, Liang Shen, Dongfeng Zhang, Xiaoli Shen
Chronic Diseases Prevention Review 2020 4(15)36-44; published online  25 August  2020
Abstract: The present meta-analysis was conducted to estimate the pooled prevalence of EDS in PD and explore the association of PD with the risk of EDS. PubMed, EMBASE, and Web of Science database were systematically searched up to Apr 2020, aim to find observational studies on investigating excessive daytime sleepiness in Parkinson disease. Random effects models were selected to evaluate the pooled prevalence of EDS in PD and the Odds Ratio (OR) of EDS in PD comparing with healthy control. Subgroup analysis and meta-regression were conducted to explore sources of heterogeneity. The funnel plot and Egger test were used to assess publication bias. Thirteen articles with 3912 participants were included to pool the prevalence of EDS in PD. The pooled prevalence of EDS in all PD patients was 30% (95% CI: 24%-36%). Ten articles with a total number of 1375 PD patients and 1161 age-matched health controls were enrolled to evaluate the association between PD and the risk of EDS. The pooled OR for the risk of EDS in PD was 2.86 (95% CI: 1.89-4.33), indicating that PD was significantly associated with an increased risk of EDS. EDS may cause diminished life quality and hazardous accidents in PD patients, early prevention and interventions of EDS were essential in the treatment of PD.

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