5. 11. 2022   

Chronic Diseases Prevention Review (Online ISSN: 2158-0820)

Current Issue

Vol.6  No.23

Article: Effect of Combined Spinal-epidural Anesthesia Combined with Intraoperative Tourniquet Release Management on Oxygen Saturation in Patients with Joint Replacement
by Shaowu Huang, Xia Xia, Zhengsong Wan, Zaiping Wang
Chronic Diseases Prevention Review 2022 6(23) 1-6; published online  30 December 2022
Abstract: Objective: To explore clinical significance of patient-controlled epidural analgesia (PCA) in elderly patients with acute herpes zoster neuralgia.
Methods: 44 elderly patients with herpes zoster neuralgia were divided into C and D groups according to puncture date. All patients underwent epidural puncture on corresponding skin lesions, intubation, and connection to PCA pumps equipped with compound anti-inflammatory and analgesic solutions. In group C, the epidural catheter was inserted into the affected side under the verification of the C arm. In group D, the steel wire was pulled out before the catheter was inserted, and the epidural catheter was routinely inserted. The pain was evaluated by NRS.
Results: On the 3rd, 5th, 7th and 30th day of treatment, the NRS scores of the two groups were significantly different from those before treatment and there was a significant difference between the two groups. The total amount of medication in group C was low, and the difference between the two groups was significant. The puncture-related complications of the two groups were not statistically significant.
Conclusion: The epidural PCA infusion in the lateral space was more effective than the conventional PCA in relieving the pain of herpes zoster neuralgia in the chest and abdomen.

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Article: Efficacy of Dendrobium officinale in non-gonococcal urethritis and its potential targets
by  Weiqiang He,  Jijiong Qiu
Chronic Diseases Prevention Review 2022 6(23) 7-12; published online  30 December 2022
Abstract: Objective: To observe the effect of Dendrobium officinale combined with Liuwei Dihuang decoction in the treatment of Non-gonococcal urethritis (NGU), and to predict the main components and targets of D. officinale in the treatment of NGU by network pharmacology. Methods: One hundred male patients with non-gonococcal urethritis admitted to hospital outpatient clinics were selected and divided into two groups of 50 patients each according to the treatment method. The total effective rate, adverse reaction rate and recurrence rate of the two groups were recorded and counted. The active ingredients of D. officinale were obtained by using the scifinder database, and the docking simulation tool SwissTargetPrediction (swisstargetprediction.ch) (probability > 0), SEA (sea.bkslab.org) (P < 0.05) for predicting the action targets of Dendrobium officinale chemical components. Results: D. officinale combined with Liuwei Dihuang decoction had significant therapeutic effects on NGU, and Dendrobium officinale compounds could potentially modulate 123 targets. Eleven important pathways were screened using WGC, among which, MAPK pathway was associated with inflammation. Conclusion: the combination of Liuwei Dihuang formula and D. officinale in the treatment of non-gonococcal urethritis can reduce the inflammatory response, improve the symptoms, enhance the efficacy and reduce recurrence.

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