Friday, 29. 7. 2016    

Cancer Cell Research (Online ISSN: 2161-2609)


Current Issue

Vol.3  No.11


Article: Heterotopic gastric mucosa in the gallbladder
by  Qingyu Zhao, Zusen Wang
Cancer Cell Research 2016 3(11) 251-252; published online 5 June 2016
Abstract: We report on a case of heterotopic gastric mucosa i in the gallbladder neck. A 45-year-old woman,who had been recurrent vomiting 5 months,visited our hospital because of a occupying lesion in the gallbladder, discovered by the abdominal ultrasonography. Ultrasonography revealed a highly echogenic lesion in the gallbladder neck,with gallstones in the gallbladder. The gallbladder was confirmed by the CEUS (ultrasound contrast ). Laparoscopic cholecystectomy was performed because of the possibility of the gallbladder carcinoma. The excised gallbladder measured 5 x 4 cm and was found one thickening part which was in size of 1.0 x 1.0cm. Pathologically, the polypoid lesion consisted of heterotopic gastric mucosa.

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Article: Olmesartan for the treatment of primary hypertension patients and its influence on inflammatory factors
by  Miaomiao Zhu, Jianhui Tian
Cancer Cell Research 2016 3(11) 253-256; published online 5 June 2016
Abstract: This paper aims to study the expression of inflammatory cytokines in plasma of patients with essential hypertension and antihypertensive effect of olmesartan patients with essential hypertension and the effect on plasma inflammatory factors. Will be in accordance with the guidelines of hypertension prevention and control standard collection of 100 cases of primary hypertension patients,randomly and evenly divided for 2 groups into the experimental group and the control group, and given a dose of olmesartan and valsartan treatment for 10 weeks. Before and after treatment were measured with sitting or lying right brachial artery blood pressure and fasting 12 hours of venous blood, were observed and compared before and after treatment patients with blood pressure and serum inflammatory factors changes. Treated with oral medication after 10 weeks experimental group and control group, the blood pressure decreased significantly, the difference was statistically significant (P <0.01) compared with that before treatment,and the blood pressure of the olmesartan group decrease slightly greater than in the valsartan group, but the difference between the two groups was no significant (P> 0.05); compared with before treatment, hs-CRP, TNF-α levels were significantly decreased, NO levels were increased, compared to before treatment the two groups were statistically significant (P <0.01), And olmesartan plasma levels of inflammatory factors decline slightly larger than valsartan group, hs-CRP changes between the two groups showed no significant difference (P> 0.05), while TNF-α and NO levels between the two groups the difference was statistically significant (P <0.01). Olmesartan smoothly and effectively lower blood pressure, and can be more effective in reducing the degree of abnormality of plasma levels of inflammatory factors expression.

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Article: Evaluation of bone remodeling ability in transalveolar elevation osteomes with two different methods—without or with coral bone substitute
by  Shan Shen, Chunlei Zhang, Jingxia Tang
Cancer Cell Research 2016 3(11) 257-261; published online 6 June 2016
Abstract: To evaluate the degree of osteogenesis achieved by using a coral bone substitute and a space holding device in transalveolar maxillary sinus floor elevation procedures. 33 patients were received treatment with a maxillary posterior implant in the Dental Medical Center of the First Affiliated Hospital of Jinan University between January 2013 and June 2014. The vertical bone defect in the implant region was 3.8 mm on average in all patients. The 33 patients were randomly classified into two groups: the simple closed maxillary sinus augmentation group (n=17) and the closed maxillary sinus augmentation group with the coral bone substitute (n=16). A total of 40 dental implants (Dentium, Korea) were implanted: 20 were used for the simple closed maxillary sinus augmentation and 20 were used with the coral bone substitute. Neoplastic bone formation was significantly less in patients that underwent simple closed maxillary augmentation compared with those that underwent the closed maxillary augmentation with the coral-based bone scaffold (P<0.01). In closed maxillary sinus augmentation, a coral-based bone scaffold allows us to predict the bone volume and promotes osteogenesis compared to implants without a bone substitute.

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Article: The Significance of NBI-ME on Chronic Gastritis with Intestinal Metaplasia
by  Yan Wang, Tao Mao, Qingxi Zhao
Cancer Cell Research 2016 3(11) 262-265; published online 28 June 2016
Abstract: In order to prevent the occurrence of gastric cancer, it is very important to find early gastric cancer and precancerous lesions timely. This research discussed diagnostic value of methylene blue staining under white light endoscopy, light blue crest (LBC) and white opaque substance (WOS) under NBI-ME on chronic gastritis with intestinal metaplasia. 227 patients who accepted gastroscopy in our hospital and met the inclusion criteria were selected. Olympus GIF-HQ290 electronic gastroscope was applied to finish examination under the common white light mode, to observe whether there was LBC and WOS under the NBI-ME mode and to observe whether there was baby blue staining area under the methylene blue staining. Biopsy mucosae were conducted on the diseased region. Biopsy histopathology was diagnosed as a “golden standard”. Moreover, the relation between special performance and pathology of intestinal metaplasia under three endoscopes was compared. 227 patients were examined, showing that sensitivity, specificity, positive predictive value and negative predictive value of methylene blue were 97.01%, 98.75%, 97.01% and 98.75%, respectively. These of LBC were 80.60%, 97.50%, 93.10% and 92.31%, and these of WOS were 82.09%, 96.88, 91.67% and 92.81%. All of them conducted a chi-square test with pathological results and P>0.05. Three kinds of special performance under the endoscope had higher consistency with pathological results. Three kinds of special performance under the endoscope had higher consistency with pathological results. Methylene blue staining under the gastroscope, LBC under NBI-ME and WOS can be used as a simple and effective method to judge whether there is intestinal metaplasia.

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Article: Biology of hepatocellular carcinoma restrained through tumor infiltrating macrophages
by  Dongxia Wu, Xinxin He, Ximing Shen
Cancer Cell Research 2016 3(11) 266-269; published online 25 July 2016
Abstract: To study the biology of hepatocellular carcinoma restrained through tumor infiltrating macrophages. Mononuclear cells were isolated from healthy adult peripheral blood by density gradient centrifugation and inducedwith IL-4 for selective activation of macrophagesin vitro. Hepatocellular carcinoma cell line HepG2 were cultivate with selective activation of macrophages (M2) for 48h. The Liver cancer cell clone formation were determined by the clone tablet form experiment, and then Using scratches test observed the changes of cells infiltrating migrating ability. We Successful separation cultivate tumor giant cells. In vitro microenvironment of liver cancer, M2 can significantly promote the HepG2 cell proliferation and clone formation ability (P<0.05) after co-culture with M2 for 24 hours. The process of cell infiltration and migration were also promoted too (P < 0.05). Tumor associated macrophages can promote liver cancer cell invasion and migration. If changing the microenvironment of liver cancer, it can also control the malignant biological behavior of tumors.

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Article: Influences of siRNA on biology of hepatocellular carcinoma by specific silencing protein of PI3K/AKt signal pathway
by  Xiaofeng Yuan, Xiaojun Hu
Cancer Cell Research 2016 3(11) 270-273; published online 25 July 2016
Abstract: To study the Influences of siRNA on Biology of hepatocellular carcinoma by specific silencing protein in PI3K/AKt signal pathway, further to explore the molecular mechanism of PI3K/AKt signal pathway in the development of hepatocellular carcinoma. PI3K-siRNA and AKT-siRNA were transfected into hepatocellular carcinoma cells line MHCC-97H respectively by lipofectermine 3000, and the PI3K and Akt protein expression level in liver cancer MHCC-97H cells were detected with Western blotting method, while the Liver cancer cell proliferation and cell cycle change were determined by Transwell invasion and flow cytometry. After transfection, PI3K, and Akt protein level were significantly decreased. siRNA can significantly decrease levels of PI3K and Akt protein in MHCC-97H cell lines, and can significantly inhibit the MHCC-97H cell proliferation and the process of cell cycle. It was also can promoted apoptosis (P< 0.05). siRNA can specific silencing protein of PI3K/AKt signal pathway, and to control the malignant biological behavior of tumors. PI3K/AKt signal pathway can become a new target for clinical treatment.

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Article: Analysis on high-risk factors of lesion residual after undergoing conization of cervix
by  Hongfei Xie, Yankui Wang
Cancer Cell Research 2016 3(11) 274-279; published online 25 July 2016
Abstract: To prevent cervical intraepithelial neoplasia (CIN) and relapse of cervical cancer, we have to analyze the high-risk factors of lesion residual after undergoing conization of cervix. Regression analysis upon data of clinical case of 267 patients after undergoingcold knife conization of cervix of two times will be carried out, in order to analyze the high-risk factors of lesion residual after operation. There are 74 patients with lesion residual after undergoing cold knife conization among the 267 patients. Result of single-factor analysis shows that involved gland (P=0.003), involved number of quadrant of cervix uteri >2 (P=0.006) and incisal margin involvement (P=0.002) are all relevant factors of lesion residual after undergoing conization of cervix. The result shows that positive incisal margin after operation is the independent risk factor (P=0.022) for lesion residual after Logistic regression analysis upon relevant factor has been implemented. Involved gland, involved number of quadrant >2 and incisal margin involvement are high-risk factors of lesion residual after undergoing conization of cervix, among which the incisal margin involvement has to be paid much attention.

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Article: Meta-analysis of relationship between pathological substaging and prognosis of superficial bladder cancer
by  Xin Yan, Qinchao Yu
Cancer Cell Research 2016 3(11) 280-285; published online 28 July 2016
Abstract: To systematically evaluate the value of pathological substaging of different superficial bladder cancer. This is a meta-analysis of retrospective cohort studies. The main outcome measures were progression and recurrence percentage. Computer-based online search was carried out in EMBASE, PubMed, CNKI (China National Knowledge Infrastructure), Wanfang and Google Scholar and case-control studies related to the application of pathological subtstaging in the prognosis of superficial bladder cancer. The quality of the studies included was assessed by Newcastle-ottawa scale. Data were extracted from the studies by two independent reviewers. The Meta-analysis was performed by following the specific steps described in Stata 12.0 A total of 14 case-control studies involving 2388 patients were included. These 14 studies were divided into three groups (T1mVS T1e, T1aVST1bc and T1abVST1c) according to the different substages of bladder cancer. There were no statistically significant differences in the association of pathological substaging with disease recurrence, while two groups showed statistically significant difference in the association of pathological substaging with disease progression (T1m VS T1e, HR=2.27, 95%CI=1.44-3.69, T1aVS T1BC, HR=2.22, HR 95%CI=1.68-2.95>1, suggesting statistical significance). For normuscle invasive bladder cancer, different substages of bladder cancer had no significant differences in the association of pathological substaging with disease recurrence, but two groups showed statistically significant differences in in the association of pathological substaging with disease progression. This suggests that the new methods of pathological substaging have a positive meaning for predicting the progression of bladder cancer. However, we still need larger prospective clinical randomized controlled trials to confirm our conclusion.

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