Cancer Cell Research (Online ISSN: 2161-2609)

Cancer Cell Research 2020 7(25) 666-670; published online  28 January 2020

Abstract: To investigate relationship of PCT, D-dimer, NT-ProBNP level and pulmonary function in asthmatic children with pulmonary arterial hypertension. Eighty children with asthmatic diseases were elected from admitted inpatient during October 2017 to September 2019, according to whether combined pulmonary hypertension patients can be divided into pulmonary artery hypertension group (30 cases) and non pulmonary arterial hypertension group (50 cases). PCT, D-dimer and NT-ProBNP were detected and compared between the two groups. The Pulmonary function (VT/kg, Ti/TE, TpTe/TE, Vptef/VE) were detected and compared between the two groups. There was a positive correlation between NT-ProBNP, D-dimer and PASP. The levels of PCT, D-dimer and NT-ProBNP in pulmonary arterial hypertension group were higher than those in non pulmonary arterial hypertension group (P<0.05). The levels of MV, VT/kg, Ti/TE, TpTe/TE and Vptef/VE in the pulmonary arterial hypertension group were lower than those in the non pulmonary arterial hypertension group (P<0.05). There was a positive correlation between NT-ProBNP, D-dimer and PASP. The levels of PCT, D-dimer and NT-ProBNP in the pulmonary arterial hypertension group were significantly higher than those in the non pulmonary arterial hypertension group. There are different degrees of small airway obstruction in asthmatic diseases. The degree of pulmonary function decline in pulmonary arterial hypertension group was more obvious than that in non pulmonary arterial hypertension group.

Cancer Cell Research 2020 7(25) 671-675; published online  28 January 2020

Abstract: This work was to explore the clinical characteristics and the efficacy of thoracoscopy surgery of pulmonary sclerosing pneumocytoma (PSP). The clinical features, imaging, pathology and surgical methods of 35 patients with PSP treated by video-assisted thoracic surgery (VATS) in the affiliated Hospital of Qingdao University from January 2014 to January 2019. All cases were screened and collected for retrospective analysis. 35 patients, 32 were female and 3 were male, average age of 52.69 ± 10.23. The cases in different methods VATS wedge resection, segmental resection, lobectomy, compound lobectomy, lymph node dissection were 17, 11, 5, 2, 4 respectively, and all lymph nodes were negative. The postoperative complication rate was 8.57%. The average follow-up time was 35.6 months. 2 cases were lost to follow-up. The other 33 patients survived well without recurrence, metastasis, or death. VATS can confirm the histopathology and remove the lesion. At present, it is the most effective method for the treatment of PSP, and the patient has a good prognosis.

Cancer Cell Research 2020 7(25) 676-681; published online  28 March 2020

Abstract: To investigate the value of seven autoantibodies (P53, PGP9.5, SOX2, GAGE7, GBU4-5, MAGE A1 and CAGE) in the diagnosis of lung cancer, and the correlation between seven autoantibodies and four traditional tumor markers (CEA, NSE, CYFRA 21-1, ProGRP) in lung cancer. From January to May in 2019, the serum of 60 newly diagnosed lung cancer patients and 57 healthy people from the Affiliated Hospital of Qingdao University was collected. Seven autoantibodies were detected by enzyme-linked immunosorbent assay (ELISA), the correlation between data and tumor markers was analyzed by Spearman test. In our study, the serum concentrations of P53, SOX2, PGP9.5, GAGE7, MAGE A1, CAGE and GBU4-5 in lung cancer group were higher than those in healthy group (P<0.05). Furthermore, GAGE7 was positively correlated with CEA and CYFRA21-1; GBU4-5 was positively correlated with CYFRA 21-1 (P<0.05). The correlation between autoantibodies and tumor markers is different in various pathological types. Moreover, in the difference TNM stages of tumors, there was a statistically significant difference in the positive rates of P53 in stages Ⅰ-Ⅱ and stages Ⅲ-Ⅳ (P<0.05). There were no significant differences in the positive rates of P53, PGP9.5, SOX2, GAGE7, GBU4-5, MAGE A1 and CAGE in lung cancer group by age, gender, smoking, and pathological types (P≥0.05). These results suggest that the combined detection of seven autoantibodies and four tumor markers can improve the early diagnosis of lung cancer.

Cancer Cell Research 2020 7(25) 682-686; published online  28 March 2020

Abstract: Explore the related factors affecting the prognosis of children with acute lymphoblastic leukemia. Clinical data of 48 newly diagnosed children were collected with ALL in the Yantai Yuhuangding Hospital from Janurary 2016 to December 2018. Statistics of the children's gender, age, immunophenotype, abnormal chromosome karyotype and fusion gene screening and other indicators were analyzed the relationship with prognosis. There were 48 children diagnosed acute lymphoblastic leukemia, 31 boys and 17 girls, the average age is 5.2 years. There were 45 cases of B-ALL, 3 cases of T-ALL. 30 cases were normal for chromosome karyotype, 18 cases were abnormal. 12 cases were positive for fusion gene: TEL/AML1 5cases, MLL/AF4 2cases, E2A/PBX1 3cases, MLL/AF9 1case and FLT3-ITD 1 case. Of all the patients, 6 cases died, among them, 1 case was without abnormal chromosome karyotype and fusion gene, 2 cases were both of abnormal chromosome karyotype and fusion gene, 2 cases were abnormal chromosome karyotype and fusion gene in once case. Detection of age, sex, immunophenotype, chromosome karyotype and fusion genes is essential for the prognosis of childhood acute lymphoblastic leukemia.