Cancer Cell Research (Online ISSN: 2161-2609)

by  Guiming Fu, Zhaohui Wang, Jin Chen, Yibo Chen, Chunhua Li

Cancer Cell Research 2017 4(16) 382-385; published online 27 September 2017

Abstract: The regional lymph node metastasis rate of thyroid cancer has been reported to be approximately 12.60%; parapharyngeal space (PPS) lymph node metastasis is even more rare and usually occurs as a result of postoperative recurrence and metastasis. In this paper, we describe two highly challenging cases of thyroid cancer with lymph node metastasis to the PPS that were surgically resected from 2015-2017. Two cases of thyroid cancer were successfully treated by surgery using the traditional transcervical approach. Neither patient had severe postoperative complications. To date, the patients have not experienced recurrence or other metastasis (19 months for one patient and half a year for the other patient). Parapharyngeal lymph node metastasis of thyroid cancer is rare and usually occurs as a result of postoperative recurrence and metastasis. Complete surgical resection and radioactive iodine treatment (RAI) are the primary methods used to treat the disease. Preoperative computed tomography and magnetic resonance imaging (CT/MRI) examination to select an appropriate surgical approach is crucial to a successful operation.

by  Weinan Li, Zhengwei Leng, Gang Yang, Yong Li, Qiang Li, Gang Shi, Jingdong Li

Cancer Cell Research 2017 4(16) 386-388; published online 27 September 2017

Abstract: Hepatic paragonimiasis is a form of ectopic infestation disease which can be caused by paragonimus. In this case report, we reported a case was diagnosed and treated as a hepatic paragonimiasis in 2015 in our hospital. The patient was accepted left lobotomy resections. Pathologic diagnosis showed that parasitic disease on the left liver lobe. Then is diagnosed as paragonimiasis. But the symptoms and recurrence was not found during follow-up period for 4 months.

by  Lili Li, Jing Zhao, Yufen An, Yunxiang Zhang, Zhimin Wei

Cancer Cell Research 2017 4(16) 389-398; published online 27 September 2017

Abstract: Young breast cancer patients are a special group. And the research about this group is very seldom. To investigate the relationship between molecular classification and clinicopathological features of young breast cancer patients, and the differences of those features between young and middle aged patients. A total of 2488 incident cases of invasive breast cancer were identified from the Affiliated Hospital of Qingdao University between April 2012 and August 2015. To analyze the relationship between molecular subtypes and histologic grade, tumor size, lymph node involvement, the expressions of EGFR、TopoⅡα、Ki-67 of 177 cases of young breast cancer patients (<or＝35 years old ). 2311 cases of middle aged breast cancer patients (>or＝45 years old ) during the same period were served as the control group. A meaningful correlation was detected between molecular subtypes and histologic grade, tumor size, the expressions of EGFR、TopoⅡα、Ki-67 in young breast cancer patients (Z=11. 321～38. 371，χ2=31. 886，F=27. 241，P<0. 05). In addition, the histologic grade、the expressions of TopoⅡα and Ki-67 were statistically different between young and elderly breast cancer patients (P<0. 05), especially in Luminal B subtype. Significant differences in histologic grade of Luminal B subtype, the expression of TopoⅡα of Luminal B（HER2-）subtype and the expression of Ki-67 of Luminal B（HER2+）subtype were observed between young and middle aged breast cancer patients (Z=-2. 151～-2. 027，t =2. 129，P＜0. 05). The molecular classification of young breast cancer patients is related to their pathological features. Some pathological characteristics of Luminal B subtype of young breast cancer patients are unique compared to the middle aged ones. It is very important to estimate prognosis and formulate individualized treatment plan based on the precise medical treatment.

by  Xin Li, Yingjie Chen, Xiao Jiang, Wei Jiao, Yuhua Song 

Cancer Cell Research 2017 4(16) 399-403; published online 27 October 2017

Abstract: Paraneoplastic neurological syndrome (PNS) is a rare immune-mediated syndrome occurring in less than 1-3% of patients with breast cancer. Two rare cases of paraneoplastic cerebellar degeneration with breast carcinoma were reported here with a brief review of the pertinent literature. The primary indications of these two female patients were progressive lower limb weakness and gait ataxia. Both from a clinical standpoint, as well as from the results of the performed staging examination. There was no reason to suspect breast cancer. The primary tumor previously reported was often occult. However, in our reports, autoimmune anti-Yo antibodies in the cerebrospinal fluid and serum were positive. The indication of anti-Yo antibodies led to the conclusion of the existence of paraneoplastic cerebellar degeneration. The awareness of detectable antibodies may help to enclude more common causes of neurological dysfunction.

by  Huafeng Zhang, Yanting Luo 

Cancer Cell Research 2017 4(16) 404-407; published online 27 October 2017

Abstract: To evaluate the feasibility of iDOSE iterative reconstruction technique in reducing body radiation dose at enhanced CT of liver tumors. 65 patients with known or suspected liver tumors were underwent hepatic enhanced 256 slice CT scan. Routine and low dose CT scans were acquired sequentially during the hepatic portal venous phase after contrast injection. Routine dose data were reconstructed by using filtered back projection (FBP, group A), low dose acquisition with FBP (group B) and seven different levels of iterative reconstruction algorithm (iDOSE1-iDOSE7, group C). Quantitative noise and CNR measurements were performed. Sharpness of tumors, contrast between tumors and normal liver tissue and image quality were graded and compared among three groups. Low dose acquisitions were obtained with 71% dose reduction. Group C had the lowest image noise (P=0. 001) and had the highest CNR of iDOSE1-iDOSE7 than that of FBP (P=0.001). No significant difference of SNR and CNR values were found among iDOSE2, iDOSE3, iDOSE4. Group C obtained identical observer image quality scores than group A (P>0.05). The iDOSE iterative reconstruction technique can enables 50% radiation dose reduction in CT imaging of liver tumors, while maintains the diagnostic quality of routine dose CT.