Cancer Cell Research (Online ISSN: 2161-2609)
Current Issue
Vol.3 No.9
Article: Clinical study of FOLFIRI treatment for gastric cancer patients with metachronous ovarian metastasis
by Xiaodan Wang, Ping Sun
Cancer Cell Research 2016 3(9) 210-213; published online 25 January 2016
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Article: Study effect and mechanism of andrographolide on breast cancer cell MCF-7 and HCT116
by Songyan Hu, Youfeng Guo
Abstract: The aim of this study was to investigate the inhibitory effect of andrographolide on breast cancer cell line MCF-7 and HCT116 proliferation and its mechanism. MCF-7 and HCT116 in breast cancer cell were collected in vitro, according to different concentration of andrographolide (AND) dealt were divided into four groups, 15mol/LAND was as low concentration group, 30 mol/L AND was as middle concentration group, 60 mol/L AND was as high concentration group, no AND dealt was as blank control group, cell proliferation was detected by MTS, morphological change of cells were observed by microscope, apoptosis related proteins Caspase-3, Caspase-9 and Bal-2 mRNA express were detected by RT-PCR. The result showed that the cell proliferation inhibition rate of AND dealt groups were significantly increased, and with different concentration and dealt time changed significantly, AND concentration was high, the dealt time was longer, cell proliferation inhibition rate were higher (P<0.05), the microscope showed, MCF-7 and HCT116 cell shrinkage, shedding, assume apoptosis. With AND concentration increasing, Caspase-3, Caspase-9mRNA express gradually increased, Bal-2 mRNA express gradually weakened, comparison between groups with significant difference (P<0.05). Andrographolide on breast cancer MCF-7 and HCT116 cell proliferation has obvious concentration and time dependent inhibition effect, its mechanism may be down-regulating Bal-2 or up-regulating Caspase-3, Caspase-9 protein express.
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Article: The Expression and Significance of Angiopoietin-2 and Glucose Regulated Protein78 in Colorectal Cancer
by Weiyan Du, Chen Qin, Jing Xu, Xuezhen Ma
Cancer Cell Research 2016 3(9) 219-222; published online 25 January 2016
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Article: Preparation and evaluation of liver targeting nano device based on Graphene Oxide mediated Miriplatin delivery
by Chao Ma, Miao Yu, Guowen Yan, Ying Zhang, Chen Wei, Jiao Liu, Lutao Jiang, Jialing Dai,
Yitong Li, Yong Sun
Cancer Cell Research 2016 3(9) 223-229; published online 25 January 2016
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