Cancer Cell Research (Online ISSN: 2161-2609)
 |
Current Issue
Vol.1 No.2
Article: Association of Hyperglycemia, Hyperlipemia with the Risk of UterineLeiomyomata: A Case-Control Study
by Shujun Kong, Jianqing Hou,Min Xia, Ying Yang, Anli Xu, Qing Tang
Cancer Cell Research 2014 1(2) 37-41; published online 8 March 2014
Abstract: Uterine leiomyoma are common noncancerous tumors of the uterus and are the most frequent reason for recommending a hysterectomy. This study was conducted to investigate the associations between uterine leiomyoma and lifestyles including glucose metabolism, lipid metabolism and obesity. The case-control study was conducted from January 1st 2012 to December 31st 2012 at Yuhuangding Hospital in Yantai. All Uterine fibroid patients were confirmed by postoperative pathology. This case-control study composed of 165 cases and 165 controls. The adjusted odds ratio (OR) and 95% confidence interval (CI) were estimated using unconditional logistic regression.For premenopausal women, fasting plasma glucose (FPG) (OR=0.09; 95% CI: 0.003-0.029) and HDL-C/LDL-C (OR=0.01; 95% CI: 0.002-0.114) significantly decreased the risk of uterine leiomyoma. Conversely, total cholesterol (TC) (OR=6.70; 95% CI: 3.816-11.764) and body mass index (BMI) (OR=1.36; 95% CI: 1.226-1.517) significantly increased the risk. This study suggested protective roles for higher level of HDL-C and FPG on uterine leiomyoma, and supported the hypothesis that lower level of TC and BMI may reduce uterine leiomyoma risk among premenopausal women.
Open Access Download (free) PDF
Article: A clinical investigation of electrosurgical knife burning to treat Blandin-Nuhn mucoceles
by Zhenpeng Zhao, Yuanyong Feng, Lingxue Bu, Wei Shang
Cancer Cell Research 2014 1(2) 42-46; published online 8 March 2014
Abstract: The aims of the present study were to investigate a new technique to treat the mucoceles of the Blandin-Nuhn gland, to evaluate the clinical effect of applying an electrosurgical knife to treat anterior tongue gland mucoceles. A total of 26 cases of tongue mucoceles were included in this study. In each case, an electrosurgical knife was used along the surface of mucoceles to excise a portion of tongue ventral mucosa and part of mucoceles without suture, and compared the recurrence vates of removal of electrosurgical knife, mucoceles alone and bilateral removal of Blandin-Nuhn glands and mucoceles. The results demonstrated that all patients were classified as class-I stage wound healing. One case relapsed during the follow-up period. The comparison of recurrence vates (P < 0.05) showed statistical significance. In the conclusion, electrosurgical knife heat-burning treatment is superior to traditional mucoceles alone and bilateral Blandin-Nuhn glands and mucocele enucleation.
Open Access Download (free) PDF
Article: Relationship between Aberrant Expression of hMSH2 and Prognosis in Patients with Sporadic Colorectal Cancer
by Zhenqiang Sun, Xianbo Yu, Haijiang Wang, Zeliang Zhao, Ruiwei Xu, Shuo Zhang, Qisan Wang,
Fa Fang, Xiaona Han
Cancer Cell Research 2014 1(2) 47-54; published online 8 March 2014
Abstract: The aim of thestudy was to investigate relationship of hMSH2 aberrant expression and clinicopathological features of patients with sporadic colorectal cancer, and to explore effect of aberrant expression on prognosis. Clinicopathologic materials and postoperative samples of 327 patients with sporadic colorectal cancer in our hospital were collected. Immunohistochemistry PV-9000 two step method was performed to measure the situation of hMSH2 expression in 327 postoperative pathologic specimens. Relationship of hMSH2 aberrant expression and clinicopathological features of patients with sporadic colorectal cancer was analyzed. Prognosis difference between the groups of normal and abnormal protein expression of hMSH2 was compared. 10.7% of the patients showed abnormal nuclear staining for hMSH2 protein expression. Aberrant hMSH2 expression of sporadic colorectal cancer mostly indicated in right hemicolon, and its histological type mainly showed mucinous adenocarcinoma and low differentiated degree. The patients with loss of protein expression of hMSH2 displayed better prognosis than normal expression group. Consequently, aberrant expression of hMSH2 plays a significant part in occurrence and development for patients with sporadic colorectal cancer and its deletion may be an independent prognostic factor.
Open Access Download (free) PDF
Article: Prospective Study of Icotinib Concurrent IMRT in Patients with Inoperable Stage Ⅲ Non-small Cell Lung Cancer
by Tiantian Li, Xuezhen Ma, Yuan Yao
Cancer Cell Research 2014 1(2) 55-64; published online 8 March 2014
Abstract: To evaluate the safety profile and efficacy of icotinib concurrent with intensity modulated conformal radiotherapy (IMRT) in previously untreated patients with inoperable Stage Ⅲ non-small cell lung cancer (NSCLC). 90 patients were enrolled in this prospective study. All patients were assessed for toxicity, and 78 patients were available for efficacy. 24 patients were treated with icotinib concurrent IMRT with curative intent. The primary endpoints were overall survival (OS). The secondary endpoints included progression free survival (PFS), local control rate and acute toxicity. Loss of appetite, leucopenia, rash, pulmonary toxicities were acceptable and manageable. Severe adverse events included pain (Grade 4, 12.5%) and leucopenia (Grade 4, 4.17%), rash (Grade 4, 4.17%). With a median follow-up of 321 days, a local control rate of 95.8% was achieved for thoracic tumor. Overall survival and median PFS were 377 days, 289 days. The current experimental data suggested that icotinib concomitant IMRT was effective and safe for patients with advanced NSCLC as first-line regimen.
Open Access Download (free) PDF