Cancer Cell Research (Online ISSN: 2161-2609)

by  Xin He, Chuanyu Zhang

Cancer Cell Research 2014 1(4) 91-95; published online 26 November 2014

Abstract: Objective: To analysis radiographic features of thoracic sarcoidosis for further understanding of the disease. Methods: 42 cases of pulmonar sarcodiosis were proved by histopathology from April 2009 to July 2014, including 13male and 29 female, and their age were from 33 year-old to 75 year-old, with an average of 50 years. All the cases underwent CT scan. Among them, 25 cases received enhanced CT scan. The imaging findings were summarized by two chest imaging physician. Results: The main CT finding of pulmonar sarcodiosis was lymphadenopathy which were seen in 38 cases (90.5%), including mediastinal and bilateral hilar lymphadenopathy (n=27, 64.3%), mediastinal and the hilar lymphadenopathy (n=5, 11.9%), mediastinal lymphadenopathy (n=6, 14.3%) and the lesion of pulmonary parenchymal without mediastinal lymphadenopathy (n=4, 9.5%). The parenchymal abnormalities in sarcoidosis were seen in 34 cases (80.9%), of which 29 cases were noudles (69.0%) and 15 cases distributed around the bronchovascular bundles (35.7%), masses (n=4, 9.5%), consolidations (n=2, 4.8%), ground-grass (n=1, 2.4%), thickening of bronchovascular bundle (n=12, 28.6%), fibrosis (n=1, 2.4%) and pelural involvement (n=10, 23.8%). Conclusion: CT manifertations of pulmonar sarcodiosis are varied, but have some specific radiographic features. A correct diagnosis can be made combined with hilar and mediastinal adenopathy.

by  Lianhua Cui, Chongchong Jiao, Yuncai Liu, Hongzong Si

Cancer Cell Research 2014 1(4) 96-99; published online 26 November 2014

Abstract: Objective: To analyze the application and clinical values of fucosylated Golgi protein 73 (Fuc-gp73) in diagnosing hepatocellular carcinoma.Methods: A total of 481 serum samples were collected, including 218 cases of HCC, 61 cases of chronic hepatitis B patients, 96 cases of liver cirrhosis, 106 cases of healthy controls, from Sep. 2011 to Apr. 2013 in Affiliated Hospital of Qingdao University Medical College. Fuc-gp73 was isolated by using microcentrifugalcolumn conjugated with Lentil Lectin (LCA), LCA affinity ELISA was used to detect the serum level of Fuc-gp73. Chemiluminescent immunoassay was used to detect the serum level of AFP. Results: The serum level of Fuc-gp73 was uncorrelated with age, gender, tumor TNM stage, tumor size and serum AFP level. Serum Fuc-gp73 level in patients with lymph node metastasis was significantly higher than that non-metastasis(P＜0.05). Fuc-gp73 level in HCC group was significantly higher than liver cirrhosis group, chronic hepatitis group and healthy control group. Fuc-gp73 level in liver cirrhosis group was significantly higher than chronic hepatitis B and healthy control groups. The area under the curve (AUC) of Fuc-gp73 and AFP in single detection for the diagnosis of HCC was 0.939 and 0.818, respectively. Fuc-gp73 had a sensitivity of 83% and a specificity of 95.1%,when the put 8.24ng/ml as the optimal cut-off point. Conclusion: Serum Fuc-gp73 was highly expressed in the patients with HCC, and its level correlated with lymph node metastasis of HCC. The diagnosis accuracy on HCC of serum Fuc-gp73 was better than serum AFP.