Cancer Cell Research (Online ISSN: 2161-2609)

by  Hongwei Si

Cancer Cell Research 2018 5(19) 464-470; published online  6  April 2018

Abstract: About 90% of our time is spent indoors where we are exposed to chemical and biological contaminants and possibly to carcinogens. These agents are highly associated with the increased rates of nonspecific respiratory and neurologic symptoms, allergies, asthma and lung cancer. We reviewed the sources, health effects and control strategies for these agents, particularly the major carcinogens from contaminated indoor air. While the fundamental approaches including quitting smoking and using natural and healthy building materials are essential of eliminating indoor air contamination, some simple measures such as increasing ventilation in the central heating, ventilation and air-conditioning systemsand daily opening windows may be realistic, convenient and cost-effective ways to improve indoor air quality and health for homeowners.

by Shengrong Lv, Xinjia He, Yongheng An

Cancer Cell Research 2018 5(19) 471-476; published online  10 April 2018

Abstract: Esophageal cancer is one of the top ten tumors in the world and radiotherapy is an important treatment method. Due to the interference of many factors, increasing theradiotherapy sensitivity of tumor cells has become an important part of the treatment. Curcumin is a traditional Chinese medicine. Many studies showed that curcumin has radiosensitivity by inducing apoptosis, regulating cell cycle, increasing DNA damage in tumor cells and restraining repair in hypoxic cell. The study of radiotherapy sensitivity of curcumin on esophageal cancer will bring a new opportunity for clinical application.

by Kefei Mu, Jianwei Du, Zhaoyong Sun, Dawei Zhang, Yanwei Cao, Yong Liu

Cancer Cell Research 2018 5(19) 477-483; published online  15  April 2018

Abstract: As an inhibitor of apoptosis protein, survivin was abundantly expressed in many human malignancies. Although many studies have demonstrated the relationship between the survivin-31C/G (rs9904341) polymorphism and urinary system cancer susceptibility, the conclusions remained controversial. In order to clarify the effects of this polymorphism on the risk of urinary system cancer, a comprehensive meta-analysis was performed. Six databases were searched to identify the eligible studies. Pooled odds ratios (ORs) with 95% confidenceintervals (CIs) were calculated under the allelic, dominant, homozygous, heterozygous and recessive models. The data were analyzed by using the Stata 12.0. Nine case-control studies were included with a total of 2307 cases and 2722 controls. The results indicated that Survivin-31C/G (rs9904341) polymorphism was associated with increased risk of urinary system cancer (OR=1.28 95%CI=1.01-1.62, P=0.039). Stratified analysis by ethnicity (Asian and Caucasian) indicated thatSurvivin-31C/G variants were associated with a significantly increased risk of urinary system cancer in Asian population (OR=1.53 95%CI=1.27-1.85, P<0.001), but associated with a reduced risk of urinary tract cancer in Caucasian (OR=0.29 95%CI=0.13-0.64, P=0.002). This meta-analysis suggested that the Survivin-31C/G (rs9904341) variants increased the urinary system cancer predisposition in Asian population, and reduced the urinary system cancer predisposition in Caucasian.

by Xiaoyan Gu, Pengfei Xu, Sujuan Xu

Cancer Cell Research 2018 5(19) 484-488; published online  30 June 2018

Abstract: To analyze the relation between the expression of RP11-597D13.9 and prognosis in serous ovarian cancer (SOC) patients via The Cancer Genome Atlas (TCGA) database, we downloaded clinical information of SOC patients from TCGA and downloaded the lncRNA expression data from The Atlas of Noncoding RNAs in Cancer (TARNIC) database. 2 and t test were used to analyze the association of RP11-597D13.9 and the clinicopathological features of SOC patients. Kaplan-Meier was used to analyze the relationship between the expression of RP11-597D13.9 and the overall survival of SOC patients. Univariate and multivariate COX regression was further used to analyze whether RP11-597D13.9 was an independent prognosis marker of SOC patients. Our results showed that RP11-597D13.9 expression level was not associated with age, TNM and grade but associated with survival status (P=0.002) and race (p=0.049). Compared with patients with low expression level, SOC patients with high RP11-597D13.9expression level had shorter overall survival time. Besides this, the RP11-597D13.9 expression level in deceased patients significantly higher than living patients. Univariate and multivariate COX regression analysis showed that age and RP11-597D13.9 are the indicators of the prognosis of patients with SOC. Therefore, positive expression of RP11-597D13.9 could be an important independent marker of poor prognosis in patients with SOC.