Friday, 24. 8. 2018    

Cancer Cell Research (Online ISSN: 2161-2609)


Current Issue

Vol.5  No.20


Article: Mechanisms of Anti-prostate Cancer by Polyphenols Compounds
by  Xi Meng, Fucheng Song, Hongzong Si
Cancer Cell Research 2018 5(20) 489-495; published online  30  August 2018
Abstract: Prostate cancer (PCa) is the most common cancer in the world, it is greatly affected by lifestyle, particularly diet, and is more prevalent in US and European countries compared with South and East Asia. Among several known causes and risk factors, nutrition plays an important role in PCa pathogenesis. And the relationship between dietary polyphenols and the treatment of PCa has been examined previously. There is a general agreement that polyphenols compounds hold great promise for the future management of PCa. Generally considered as non-toxic, polyphenols compounds act as key modulators of signaling pathways and are therefore considered ideal chemopreventive agents. Besides possessing various anti-tumor properties polyphenols compounds also contribute to epigenetic changes associated with the fate of cancer cells and have emerged as potential drugs for therapeutic intervention. This report reviews current knowledge on the anti-prostate cancer effects of several polyphenols compounds, with a focus on their ability to modulate multiple signaling transduction pathways involved in cancer.

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Article: Membrane-type 1 matrix metalloproteinase (MT1-MMP): expression, targets, inhibitors and biological functions 
by  Zao Dai, Tian Yang, Min Ke, Shan Lu, Ping Liu
Cancer Cell Research 2018 5(20) 496-506; published online  30  August 2018
Abstract: Transmembrane type 1 matrix metalloproteinase (MT1-MMP) is a multifunctional proteinase capable of targeting the extracellular matrix, growth factors, cytokines and cell surface-associated adhesion and signaling receptors. With the diversity functions, MT1-MMP plays critical roles involving in many cellular processes, such as tissue and organ development, cancer cell migration, invasion and metastasis, proper wound healing and tissue repair after inflammation, transition of cells from normalcy to malignancy, et al. This review will focus on the expression, targets and bio-functions of MT1-MMP; and will also discuss a little of future research direction about MT1-MMP.

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Article: Evaluation of curative effects of single segmental bilateral screw system implantation and resection of spinal canal neurilemmoma
by  Dexun Wang, Huacong Wang, Qizun Wang, Zhongying Wang, Shuzhong Li
Cancer Cell Research 2018 5(20) 507-510; published online  10  September 2018
Abstract: Patients who underwent single segment bilateral screw system implantation and resection of spinal canal neurilemmoma were retrospectively analyzed. A total of 38 patients underwent single segmental bilateral screw rod system implantation and spinal canal neurilemmoma resection in Laoshan Hospital, Qingdao University Affiliated Hospital between January 2016 and January 2018. Patients were followed up three months postoperatively. The Lovett score of muscle strength, visual analogue score (VAS), and Japanese Orthopaedic Association Scores (JOA) before and after surgery were analyzed to evaluate the effect of single segmental bilateral screw system implantation and spinal canal neurilemmoma resection. JOA and Lovett scores were significantly higher than preoperatively (P <0.05). The postoperative pain score was lower than preoperatively (P <0.05). Bilateral screw rod implantation and resection of spinal canal neurilemmoma may be of benefit for the treatment of spinal canal neurilemmoma.

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Article: Clinical analysis of posterior approach total laminectomy in the treatment of intravertebral schwannoma
by Huacong Wang, Dexun Wang, Xiaoxuan Gu, Yong Liu
Cancer Cell Research 2018 5(20) 511-514; published online  10  September 2018
Abstract: To investigate the effect of posterior approach total laminectomy in the treatment of intravertebral schwannoma. From January 2016 to January 2018, 50 patients with spinal schwannoma hospitalized in our hospital all underwent posterior total vertebral laminectomy in 21 males and 29 females, aged 12-78 years, with an average age of (53.12±15.01) years. All patients with intramedullary line into the road after the lamina decompression, pedicle screw fixation, re-movement of epidural tumor directly, intradural tumor line cut epidural tumor remove the epidural capsulorrhaphy all patients with incision after negative pressure drainage. Postoperative intravenous drip of antibiotics for three days were followed up for 6 to 12 months postoperatively, observe the clinical curative effect. All patients' bleeding time before surgery and JOA score 6 months and 12 months after surgery were recorded, and VAS score 6 months and 12 months after surgery were recorded. Rreview the MRI to observe whether the tumor recurrence, with the evaluation of patients with nerve functional recovery degree, review of X-ray observation of patients with spinal stability. Operation time 1-6h, an average of 2.63h±1.14, intraoperative blood loss, 100-1000ml, an average of 289.00ml±260.16. Postoperative pathological biopsy in 50 patients with tumor, proved schwannoma in 18 cases without postoperative spinal cord injury patients have different degree of cerebrospinal fluid leakage, give symptomatic treatment after rehabilitation. The posterior approach of total laminectomy and decompression can fully expose the tumors in the spinal canal, so as to facilitate the complete removal of the lesion site. The effect of this method in the treatment of intravertebral schwannoma is satisfactory. In addition, JOA score was increased after surgery, VAS score was decreased, and symptoms improved significantly.

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Article: Enhanced recovery after surgery for elderly patients with colon cancer
by Ziwen Zhao, Xiaonan Xi, Dalue Li, Zhaoli Liu, Shunzheng Wang, Jihua Xu, Dongsheng Wang
Cancer Cell Research 2018 5(20) 515-519; published online  15  September 2018
Abstract: To compare the incidence of postoperative complications, postoperative evacuation, defecation and length of stay, and analyze the effect of enhanced recovery after surgery on postoperative recovery of elderly patients with colon cancer and to provide theoretical support and evidence supplements. A retrospective analysis was performed on 169 old patients with colon cancer who were admitted to the Affiliated Hospital of Qingdao University from October 1, 2016 to October 31, 2017. According to perioperative period whether they accepted the enhanced recovery after surgery program, the cases were divided into Enhanced recovery after surgery (ERAS) group (n=77) and control group (n=92). The postoperative recovery of the two groups was compared and analyzed. The enhanced recovery after surgery was performed for elderly patients with colon cancer after surgery. In patients with ERAS, the time for exhaust, defecation, and hospitalization was significantly shorter than those of the control group .However, the postoperative complications and readmission rate of the patients in the ERAS group showed no increasing trend compared with the control group. The difference is not statistically significant. Enhanced recovery after surgery has a positive effect on the postoperative recovery of elderly patients with colon cancer, and has certain clinical significance.

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Article: Analyzing aberrantly expressed mRNA profiles in early lung squamous cell carcinoma based on TCGA data
by Jing Ning, Xiaocheng Gong
Cancer Cell Research 2018 5(20) 520-523; published online  15  October 2018
Abstract: As one of the most frequent and deadly cancers, the pathological mechanism of lung cancer has yet to be determined, especially in lung squamous cell carcinoma (LUSC). Aberrantly expressed mRNAs are the prominent contributing factor to cancer, which are important to find new biomarkers for early diagnosis and understand the etiology of LUSC. Currently, data of the Cancer Genome Atlas (TCGA) offer the potential to finish these works. This study explored the early expression profile of LUSC-specific mRNA based on a database obtained from TCGA. KEGG analysis showed that P53 signaling pathway, Wnt signaling pathway, TNF signaling pathway, PI3K-Akt signaling and so on have significantly changed in patients with LUSC. Some genes, such as cyclin-dependent kinases 1 (CDK1), minichromosome maintenance complex component 2 (MCM2) and cyclin B1 (CCNB1), are highly expressed in early LUSC, while growth arrest and DNA damage inducible beta (GADD45B), transforming growth factor-β2 (TGFB2) and cell division cycle 14A (CDC14A) and other genes showed low expression, which these genes are enriched in the p53 signaling pathway. The result obtained by KEGG analysis on differentially expressed genes in LUSC tumors are a good indicator of early detection for LUSC, and provide valuable information in future research for clarifying the etiology of LUSC.

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Article: The research progress of c-Met inhibitors in clinical trials
by Yanyan Wang, Ruyi Jin
Cancer Cell Research 2018 5(20) 524-528; published online  17  October 2018
Abstract: Mesenchymal-epithelial transition factor gene (Met) is a protein encoded by c-Met proto-oncogene, which involved in the formation, transfer, and invasion of a variety of tumors. Increased c-Met expression in several human malignancies is related to increased tumor progression and is a new potential drug target for several types of cancers. Recently, there are two c-met inhibitor drugs have been approved for marketing, meanwhile, lots of c-Met inhibitors are in clinical research. Some of them showed good potential to reach market. The purpose of this paper is to summarize the structure and biological of c-Met inhibitors in the clinical research.

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