Cancer Cell Research (Online ISSN: 2161-2609)
Current Issue
Vol.5 No.20
Article: Mechanisms of Anti-prostate Cancer by Polyphenols Compounds
by Xi Meng, Fucheng Song, Hongzong Si
Cancer Cell Research 2018 5(20) 489-495; published online 30 August 2018
Abstract:
Prostate cancer (PCa) is the most common cancer in the
world, it is greatly affected by lifestyle, particularly
diet, and is more prevalent in US and European countries
compared with South and East Asia. Among several known
causes and risk factors, nutrition plays an important role
in PCa pathogenesis. And the relationship between dietary
polyphenols and the treatment of PCa has been examined
previously. There is a general agreement that polyphenols
compounds hold great promise for the future management of
PCa. Generally considered as non-toxic, polyphenols
compounds act as key modulators of signaling pathways and
are therefore considered ideal chemopreventive agents.
Besides possessing various anti-tumor properties polyphenols
compounds also contribute to epigenetic changes associated
with the fate of cancer cells and have emerged as potential
drugs for therapeutic intervention. This report reviews
current knowledge on the anti-prostate cancer effects of
several polyphenols compounds, with a focus on their ability
to modulate multiple signaling transduction pathways
involved in cancer.
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Article: Membrane-type 1 matrix metalloproteinase (MT1-MMP): expression, targets, inhibitors and biological functions
by Zao Dai, Tian Yang, Min Ke, Shan Lu, Ping Liu
Cancer Cell Research 2018 5(20) 496-506; published online 30 August 2018
Abstract:
Transmembrane type 1 matrix metalloproteinase (MT1-MMP) is a
multifunctional proteinase capable of targeting the
extracellular matrix, growth factors, cytokines and cell
surface-associated adhesion and signaling receptors. With
the diversity functions, MT1-MMP plays critical roles
involving in many cellular processes, such as tissue and
organ development, cancer cell migration, invasion and
metastasis, proper wound healing and tissue repair after
inflammation, transition of cells from normalcy to
malignancy, et al. This review will focus on the expression,
targets and bio-functions of MT1-MMP; and will also discuss
a little of future research direction about MT1-MMP.
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Article: Evaluation of curative effects of single segmental bilateral screw system implantation and resection of spinal canal neurilemmoma
by Dexun Wang, Huacong Wang, Qizun Wang, Zhongying Wang, Shuzhong Li
Cancer Cell Research 2018 5(20) 507-510; published online 10 September 2018
Abstract:
Patients who underwent single segment bilateral screw system
implantation and resection of spinal canal neurilemmoma were
retrospectively analyzed. A total of 38 patients underwent
single segmental bilateral screw rod system implantation and
spinal canal neurilemmoma resection in Laoshan Hospital,
Qingdao University Affiliated Hospital between January 2016
and January 2018. Patients were followed up three months
postoperatively. The Lovett score of muscle strength, visual
analogue score (VAS), and Japanese Orthopaedic Association
Scores (JOA) before and after surgery were analyzed to
evaluate the effect of single segmental bilateral screw
system implantation and spinal canal neurilemmoma resection.
JOA and Lovett scores were significantly higher than
preoperatively (P <0.05). The postoperative pain score was
lower than preoperatively (P <0.05). Bilateral screw rod
implantation and resection of spinal canal neurilemmoma may
be of benefit for the treatment of spinal canal
neurilemmoma.
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Article: Clinical analysis of posterior approach total laminectomy in the treatment of intravertebral schwannoma
by Huacong Wang, Dexun Wang, Xiaoxuan Gu, Yong Liu
Cancer Cell Research 2018 5(20) 511-514; published online 10 September 2018
Abstract:
To investigate the effect of posterior approach total
laminectomy in the treatment of intravertebral schwannoma.
From January 2016 to January 2018, 50 patients with spinal
schwannoma hospitalized in our hospital all underwent
posterior total vertebral laminectomy in 21 males and 29
females, aged 12-78 years, with an average age of
(53.12±15.01) years. All patients with intramedullary line
into the road after the lamina decompression, pedicle screw
fixation, re-movement of epidural tumor directly, intradural
tumor line cut epidural tumor remove the epidural
capsulorrhaphy all patients with incision after negative
pressure drainage. Postoperative intravenous drip of
antibiotics for three days were followed up for 6 to 12
months postoperatively, observe the clinical curative
effect. All patients' bleeding time before surgery and JOA
score 6 months and 12 months after surgery were recorded,
and VAS score 6 months and 12 months after surgery were
recorded. Rreview the MRI to observe whether the tumor
recurrence, with the evaluation of patients with nerve
functional recovery degree, review of X-ray observation of
patients with spinal stability. Operation time 1-6h, an
average of 2.63h±1.14, intraoperative blood loss,
100-1000ml, an average of 289.00ml±260.16. Postoperative
pathological biopsy in 50 patients with tumor, proved
schwannoma in 18 cases without postoperative spinal cord
injury patients have different degree of cerebrospinal fluid
leakage, give symptomatic treatment after rehabilitation.
The posterior approach of total laminectomy and
decompression can fully expose the tumors in the spinal
canal, so as to facilitate the complete removal of the
lesion site. The effect of this method in the treatment of
intravertebral schwannoma is satisfactory. In addition, JOA
score was increased after surgery, VAS score was decreased,
and symptoms improved significantly.
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Article: Enhanced recovery after surgery for elderly patients with colon cancer
by Ziwen Zhao, Xiaonan Xi, Dalue Li, Zhaoli Liu, Shunzheng Wang, Jihua Xu, Dongsheng Wang
Cancer Cell Research 2018 5(20) 515-519; published online 15 September 2018
Abstract:
To compare the incidence of postoperative complications,
postoperative evacuation, defecation and length of stay, and
analyze the effect of enhanced recovery after surgery on
postoperative recovery of elderly patients with colon cancer
and to provide theoretical support and evidence supplements.
A retrospective analysis was performed on 169 old patients
with colon cancer who were admitted to the Affiliated
Hospital of Qingdao University from October 1, 2016 to
October 31, 2017. According to perioperative period whether
they accepted the enhanced recovery after surgery program,
the cases were divided into Enhanced recovery after surgery
(ERAS) group (n=77) and control group (n=92). The
postoperative recovery of the two groups was compared and
analyzed. The enhanced recovery after surgery was performed
for elderly patients with colon cancer after surgery. In
patients with ERAS, the time for exhaust, defecation, and
hospitalization was significantly shorter than those of the
control group .However, the postoperative complications and
readmission rate of the patients in the ERAS group showed no
increasing trend compared with the control group. The
difference is not statistically significant. Enhanced
recovery after surgery has a positive effect on the
postoperative recovery of elderly patients with colon
cancer, and has certain clinical significance.
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Article: Analyzing aberrantly expressed mRNA profiles in early lung squamous cell carcinoma based on TCGA data
by Jing Ning, Xiaocheng Gong
Cancer Cell Research 2018 5(20) 520-523; published online 15 October 2018
Abstract:
As one of the most frequent and deadly cancers, the
pathological mechanism of lung cancer has yet to be
determined, especially in lung squamous cell carcinoma
(LUSC). Aberrantly expressed mRNAs are the prominent
contributing factor to cancer, which are important to find
new biomarkers for early diagnosis and understand the
etiology of LUSC. Currently, data of the Cancer Genome Atlas
(TCGA) offer the potential to finish these works. This study
explored the early expression profile of LUSC-specific mRNA
based on a database obtained from TCGA. KEGG analysis showed
that P53 signaling pathway, Wnt signaling pathway, TNF
signaling pathway, PI3K-Akt signaling and so on have
significantly changed in patients with LUSC. Some genes,
such as cyclin-dependent kinases 1 (CDK1), minichromosome
maintenance complex component 2 (MCM2) and cyclin B1
(CCNB1), are highly expressed in early LUSC, while growth
arrest and DNA damage inducible beta (GADD45B), transforming
growth factor-β2 (TGFB2) and cell division cycle 14A
(CDC14A) and other genes showed low expression, which these
genes are enriched in the p53 signaling pathway. The result
obtained by KEGG analysis on differentially expressed genes
in LUSC tumors are a good indicator of early detection for
LUSC, and provide valuable information in future research
for clarifying the etiology of LUSC.
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Article: The research progress of c-Met inhibitors in clinical trials
by Yanyan Wang, Ruyi Jin
Cancer Cell Research 2018 5(20) 524-528; published online 17 October 2018
Abstract:
Mesenchymal-epithelial transition factor gene (Met) is a
protein encoded by c-Met proto-oncogene, which involved in
the formation, transfer, and invasion of a variety of
tumors. Increased c-Met expression in several human
malignancies is related to increased tumor progression and
is a new potential drug target for several types of cancers.
Recently, there are two c-met inhibitor drugs have been
approved for marketing, meanwhile, lots of c-Met inhibitors
are in clinical research. Some of them showed good potential
to reach market. The purpose of this paper is to summarize
the structure and biological of c-Met inhibitors in the
clinical research.
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