Cancer Cell Research (Online ISSN: 2161-2609)

Cancer Cell Research 2021 8(32) 813-816; published online  29 November 2021

Abstract: To explore the effect of citalopram combined with psychological intervention on cellular immune function and negative emotion in patients with primary liver cancer. 124 patients with primary liver cancer from June 2018 to August 2019 were selected. 62 in the observation and 62 in the control. In the control received routine interventional therapy for liver cancer, while in the observation were treated with citalopram combined with psychological intervention. Before and after treatment, CD3+, CD4+, CD4+/CD8+, NK cells and other cellular immune indexes were compared; core quality of life scale scores of cancer patients before and after treatment were compared; MMSE, HAMD and HAMA scores. The levels of CD3+, CD4+, CD4+/CD8+ and NK cells in the observation were higher than in the control after treatment. After treatment, MMSE 83.17 ± 4.47, HAMD 67.51 ± 7.71 and HAMA 60.42 ± 5.83 in the observation group were higher than those in the control group. Citalopram combined with psychological intervention in the treatment of patients with primary liver cancer is conducive to the protection of cellular immune function, and has positive significance in regulating patients’ mood, improving patients’ psychology and improving patients’ quality of life.

Cancer Cell Research 2021 8(32) 817-826; published online  29 December 2021

Abstract: Objective This study aimed to explore the potential mechanism of Gegen Qinlian Decoction in the treatment of radiation enteritis by means of network pharmacology. Methods The Chinese Medicine System Pharmacology Database and Analysis Platform was used to search the active ingredients and targets of Gegen Qinlian Decoction, and the relevant targets of radiation enteritis were searched online through the GeneCards and OMIM databases. Cytoscape 3.7.0 software was used to construct the interaction network of “Gegen Qinlian Decoction-active ingredient-radiation enteritis-target,” and the PPI visualization network diagram of the interaction between target and protein was drawn through STRING database analysis. R language was used to analyze the intersection of drug targets and disease targets to enrich the GO and KEGG pathways of core target genes. Results The search results obtained 146 effective active ingredients of Gegen Qinlian Decoction, including formononetin, β-sitosterol, 3'-methoxydaidzein, acacetin, 5,8,2'-trihydroxy-7-methoxyflavone, berberine, epiberberine, isorhamnetin, formononetin, kaempferol, and naringenin. The PPI network contained 101 nodes and 399 edges. The biological functions involved in GO enrichment analysis included nuclear receptor activity, ligand-activated transcription factor activity, ubiquitin-like protein ligase binding, DNA binding transcription activator activity, RNA polymerase II specific signaling, steroid hormone receptor activity, ubiquitin protein ligase binding, and activation transcription factor binding. The biological pathways and processes involved in KEGG included lipids and atherosclerosis, chemical carcinogenesis-receptor activation, fluid shear stress and atherosclerosis, Kaposi’s sarcoma-associated herpes virus infection, and apoptosis, TNF signaling pathway, and IL-17 signaling pathway. Conclusion The effective active ingredients in Gegen Qinlian Decoction treat radiation enteritis through multiple targets and pathways. This work provides a theoretical basis for further research on the effect and mechanism of Gegen Qinlian Decoction on radiation enteritis.