Cancer Cell Research (Online ISSN: 2161-2609)
Current Issue
Vol.10 No.38
Article: Adding morphine in ultrasound-guided thoracic paravertebral block for lung surgery: A prospective, randomized, controlled trial
by Qian Liu, Pengpeng Wang, Hongguang Song, Yonggang Xie
Cancer Cell Research 2023 9(38) 903-907; published online 25 March 2023
Abstract: Objectives: This study aimed to compare the efficacy and the safety of ultrasound-guided thoracic paravertebral block (TPB) using ropivacaine to TPB using ropivacaine - morphine for pain relief in patients undergoing lung surgery.
Material and methods: Our study included 100 patients after lung surgery at Yantai Yuhuangding Hospital from 09/2020 to 09/2022. Patients were divided into 2 groups: ropivacaine group (R group) (n=50) and ropivacaine-(morphine 4mg) group (RM group) (n=50). The primary outcomes were the Visual Analogue Scale (VAS) scores when patients were at rest (VR) and movement (VM). The secondary outcomes were postoperative complications (nausea, respiratory depression, lethargy, constipation, itching). The study was approved by the Ethics Committee of Yantai Yuhuangding Hospital. All participants provided their informed consent.
Results: Compared with R group, the VR and the VM was lower than RM group (p<0.05). Postoperative nausea, respiratory depression and lethargy did not have significant different between the two groups (p> 0.05). The percent of patients in the RM group undergoing constipation and itching postoperative was higher than in the R group but without statistic difference.
Conclusion: Ultrasound-guided TPB using ropivacaine - morphine is an effective intervention of pain relief after lung surgery. Its analgesic efficacy is more stronger that using ropivacaine only. Meanwhile, this method does not have more adverse reactions compared to TPB using ropivacaine.
Material and methods: Our study included 100 patients after lung surgery at Yantai Yuhuangding Hospital from 09/2020 to 09/2022. Patients were divided into 2 groups: ropivacaine group (R group) (n=50) and ropivacaine-(morphine 4mg) group (RM group) (n=50). The primary outcomes were the Visual Analogue Scale (VAS) scores when patients were at rest (VR) and movement (VM). The secondary outcomes were postoperative complications (nausea, respiratory depression, lethargy, constipation, itching). The study was approved by the Ethics Committee of Yantai Yuhuangding Hospital. All participants provided their informed consent.
Results: Compared with R group, the VR and the VM was lower than RM group (p<0.05). Postoperative nausea, respiratory depression and lethargy did not have significant different between the two groups (p> 0.05). The percent of patients in the RM group undergoing constipation and itching postoperative was higher than in the R group but without statistic difference.
Conclusion: Ultrasound-guided TPB using ropivacaine - morphine is an effective intervention of pain relief after lung surgery. Its analgesic efficacy is more stronger that using ropivacaine only. Meanwhile, this method does not have more adverse reactions compared to TPB using ropivacaine.
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